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10 The products proved to be unstable to normal flash chromatography on
silica-gel, and were therefore isolated on neutral Iatrobeads and always
kept neat.
11 M. F. Rafferty, D. S. Wilson, J. A. Monn, P. Krass, R. T. Borchardt
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In conclusion, we have presented the first catalytic highly
stereoselective conjugate hydroxylation of nitroalkenes using
oximes as easily accessible oxygen sources and bifunctional
thiurea-cinchona organocatalysts. The products obtained give
access to both optically active nitro- and aminoalcohols.
This work was made possible by a grant from Danish National
Research Foundation and the OChem Research School. P. D.
thanks the Wenner-Gren Foundation for financial support. B. N.
thanks the DAAD for financial support.
Notes and references
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´
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3648 | Chem. Commun., 2007, 3646–3648
This journal is ß The Royal Society of Chemistry 2007