European Journal of Medicinal Chemistry p. 1001 - 1007 (1998)
Update date:2022-08-29
Topics:
Tournaire-Arellano
Stigliani
Recoche
Caujolle
Payard
Linas
Seguela
Ethers of 1-(2,4-dichlorophenyl)-2-(1-H-imidazolyl)ethanol bearing influence ramification and/or unsaturated chains have been synthesized in order to specify the role of lipophilicity or steric contributions on antifungal activity against yeast for miconazole-like structures. The presence of ramifications on aliphatic chains (between 4 and 7 carbons) or unsaturation at the end, increases antifungal activity. For these compounds, lipophilicity seems to be counterbalanced by steric contributions.
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