Tetrahedron Letters p. 4823 - 4826 (1996)
Update date:2022-08-11
Topics:
Eames, Jason
Jones, Ray V.H.
Warren, Stuart
Treatment of a series of 4-RS-1,3-diols (R = Me, Et, Bn and H) with TsOH in CH2Cl2 gives substituted tetrahydrofurans. We discuss the scope of this reaction using structural variation of the migrating (RS) substituent. All reactions proceeded in high yield and give synthetically useful products.
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