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CHEMISTRY & BIODIVERSITY – Vol. 9 (2012)
NW-G08 (¼(4aS,10aR,13S,19aR,21aS,26bR,27aS,30S)-24-Chloro-2,3,4,4a,8,9,10,10a,12,13,17,18,19,
19a,22,26b,27,27a,29,30-icosahydro-26b-hydroxy-12,13-dimethyl-30-(2-methylpropyl)-7H,21aH-tripyrida-
zino[1’’,6’’:10’,11’;1’’’,6’’’:16’,17’;1’’’’,6’’’’:7’,8’][1,4,7,10,13,16]hexaazacyclooctadecino[1’,2’:1,5]pyrrolo[2,3-
b]indole-5,11,14,20,28,31(1H,16H)-hexone; 1). Amorphous white powder. M.p. 192.2–194.08. [a]D ¼
ꢀ44.5 (c¼0.25, MeOH). UV (MeOH): 205, 235. IR (KBr): 3397, 2956, 2933, 1660, 1415, 1336, 1249,
1072, 752.1H- and 13C-NMR: see Table 1. HR-ESI-MS (pos.): 771.3716 ([MþH]þ , C36H52ClN10Oþ7 ; calc.
771.3709).
NW-G09 (¼(4aS,10aR,13S,19aR,21aS,26bR,27aS,30R)-24-Chloro-2,3,4,4a,8,9,10,10a,12,13,17,18,19,
19a,22,26b,27,27a,29,30-icosahydro-25,26b-dihydroxy-12,13-dimethyl-30-(propan-2-yl)-7H,21aH-tripyri-
dazino[1’’,6’’:10’,11’;1’’’,6’’’:16’,17’;1’’’’,6’’’’:7’,8’][1,4,7,10,13,16]hexaazacyclooctadecino[1’,2’:1,5]pyrro-
lo[2,3-b]indole-5,11,14,20,28,31(1H,16H)-hexone; 2). Amorphous white powder. M.p. 225.0–226.08.
[a]D ¼ ꢀ28.0 (c¼0.25, MeOH). UV (MeOH): 205, 240. IR (KBr): 3427, 2960, 2931, 1636, 1443, 1407,
1335, 1248, 1155, 1084, 642.1H- and 13C-NMR: see Table 3. HR-ESI-MS (pos.): 773.3511 ([MþH]þ
C35H50ClN10Oþ8 ; calc. 773.3502).
,
This study was supported part by the grant of the National Key Basic Research Program (973
Program, 2010CB126100) from Science and Technology Ministry of China, the National Natural Science
Foundation of China (No.30971935), Postdoctoral Science Foundation of China (20100471644 and
201104683), and Program for New Century Excellent Talents in University from Education Ministry of
China.
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Received November 5, 2011