Organic Process Research and Development p. 2326 - 2335 (2020)
Update date:2022-08-11
Topics:
Uhlig, Nick
Martins, Andrew
Gao, Detian
Herein we report a selective DIBAL-H-mediated reduction of a heterocyclic diester to the corresponding monoaldehyde using continuous flow chemistry. The use of continuous flow enabled operation at lower temperatures and better control of the reaction time, thereby allowing for a significant increase in reaction selectivity and yield compared with batch conditions. The reaction's development as a continuous flow process and its scale-up from laboratory gram scale to multikilogram scale are discussed, including design of experiments studies to probe the optimal reaction window.
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Doi:10.1021/jo0497353
(2004)Doi:10.1007/s11243-019-00359-7
(2020)Doi:10.1016/j.tet.2006.12.042
(2007)Doi:10.1055/s-1993-25844
(1993)Doi:10.1039/d1nj00133g
(2021)Doi:10.1016/j.bmcl.2018.06.035
(2018)