ChemComm
Communication
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Mannich–base-catalyzed oxy-Michael additional reaction. The
transformation features a mild, rapid and efficient method to
synthesize densely substituted seven-membered-ring O,O-acetal
bearing a quaternary stereogenic carbon center from simple
starting precursors in moderate yields with high diastereoselectivity
and enantioselectivity. Further expansion of substrates is being
pursued in our lab.
We wish to thank the NSFC (21125209, 21332003), the MOST
of China (2011CB808600), STCSM (12JC1403800) and Specialized
Research Fund for the Doctoral Program of Higher Education
(20100076110005) for financial support.
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2198 | Chem. Commun., 2014, 50, 2196--2198
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