Tetrahedron Letters p. 2407 - 2410 (1985)
Update date:2022-08-11
Topics:
Hayes, J. A.
Brunden, M. J.
Gilham, P. T.
Gough, G. R.
Use of published procedures for photolytic removal of 2'-O-(o-nitrobenzyl) substituents from model oligoribonucleotides results in low yields of fully-deprotected products accompanied by significant amounts of oligomers carrying altered, ultraviolet light-resistant residues derived from the 2'-blocking groups.The efficiency of the deprotection has been found to be depend on pH; the side-reactions are avoided when the photolysis is carried out in solution buffered at pH 3.5.
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