Journal of Organic Chemistry p. 1172 - 1174 (1980)
Update date:2022-08-17
Topics:
Koreeda, Masato
Tanaka, Yoshio
Schwartz, Anchel
(20R)-Desmosterol, a versatile intermediate for the synthesis of vitamin D metabolites and numerous other steroids having a side chain modified at C-24 and/or C-25, can be synthesized stereospecifically and efficiently by starting from the readily available 16α,17β-epoxypregnenolone and employing the potassium-assisted oxy-Cope rearrangement as a key stereodirecting process at C-20.
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