Desmosterol

Base Information Edit

Chemical Name:Desmosterol
CAS No.:313-04-2
Molecular Formula:C27H44O
Molecular Weight:384.646
Hs Code.:
European Community (EC) Number:206-236-2
UNII:ANP93865R8
DSSTox Substance ID:DTXSID10878676
Nikkaji Number:J5.659F
Wikipedia:Desmosterol
Wikidata:Q3024529
Pharos Ligand ID:VGWQC2VWCGBL
Metabolomics Workbench ID:34376
ChEMBL ID:CHEMBL455876
Mol file:313-04-2.mol

Synonyms:24 Dehydrocholesterol;24-Dehydrocholesterol;Demosterol;Desmosterol

Suppliers and Price of Desmosterol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Desmosterol
10mg
$ 95.00

Sigma-Aldrich
Desmosterol ≥84% (GC)
10mg
$ 124.00

Sigma-Aldrich
Desmosterol ≥84% (GC)
5mg
$ 72.10

Cayman Chemical
24-dehydro Cholesterol ≥98%
5mg
$ 56.00

Cayman Chemical
24-dehydro Cholesterol ≥98%
1mg
$ 28.00

Cayman Chemical
24-dehydro Cholesterol ≥98%
10mg
$ 98.00

Cayman Chemical
24-dehydro Cholesterol ≥98%
25mg
$ 210.00

Biosynth Carbosynth
3b-Cholesta-5,24-dien-3-ol
1 mg
$ 200.00

Biosynth Carbosynth
3b-Cholesta-5,24-dien-3-ol
10 mg
$ 450.00

Biosynth Carbosynth
3b-Cholesta-5,24-dien-3-ol
5 mg
$ 360.00

Total 22 raw suppliers

Chemical Property of Desmosterol Edit

Chemical Property:

Appearance/Colour:WHITE POWDER
Vapor Pressure:2.31E-11mmHg at 25°C
Melting Point:121.5°, also reported as 119-119.5°
Refractive Index:1.535
Boiling Point:483.2 °C at 760 mmHg
PKA:15.03±0.70(Predicted)
Flash Point:209.2 °C
PSA：20.23000
Density:1 g/cm³
LogP:7.30880
Storage Temp.:−20°C
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:8.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:384.339216023
Heavy Atom Count:28
Complexity:641

Purity/Quality:

99% ^*data from raw suppliers

Desmosterol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(CCC=C(C)C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
Isomeric SMILES:C[C@H](CCC=C(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
Uses 24-dehydro Cholesterol is an immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis. Structurally, it varies from cholesterol only by a single double bond at carbon 24 and has been used as cholesterol substitute in cellular membrane studies. During brain development, 24-dehydro cholesterol transiently accumulates, composing up to 30% of total brain sterol, where it is poised to rapidly enrich membrane sterols. However, defects in cholesterol synthesis can lead to a condition called, desmosterolosis, which results in an accumulation of excess 24-dehydro cholesterol. 24-dehydro Cholesterol has been reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic lesions.[Cayman Chemical] Desmosterol has been used as a sterol to test its interaction with human protein Mincle and as an internal standard in ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). It may be used as in the preparation of lipid monolayers. A metabolite of Cholesterol (C432501).

Technology Process of Desmosterol

There total 59 articles about Desmosterol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%