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Fig. 4 (a) GPC traces of fluorescently labelled pOEGMA (top and
middle) and the control reaction to which no azide was added (bottom).
(b) GPC traces of fluorescently labelled pNIPAm (top and middle) and
the control reaction to which no azide was added (bottom).
living ATRP chain end by an azide. Furthermore, we have
demonstrated for two different monomer/catalyst pairs that this
reaction allows ATRP, azide substitution and CuAAC sub-
sequently in a one-pot procedure, with all three reactions
catalyzed by the same copper complex. This one-pot procedure
greatly simplifies the increasingly popular procedure of ‘clicking’
a functional unit to a living ATRP chain end. Moreover, the
compatibility with aqueous conditions makes this method ideally
suitable for end-functionalization of bioconjugated polymers.
The authors thank J.C. Slootweg (Medicinal Chemistry &
Chemical Biology, Utrecht University) for his kind gift of
compound 2.
c
6974 Chem. Commun., 2011, 47, 6972–6974
This journal is The Royal Society of Chemistry 2011