1-Azidoethylbenzene

Base Information

• Chemical Name: 1-Azidoethylbenzene
• CAS No.: 32366-25-9
• Molecular Formula: C8H10N3+
• Molecular Weight: 147.18
• Hs Code.: 2929909090
• Mol file: 32366-25-9.mol

Synonyms:Benzene,(1-azidoethyl);1-azido-1-phenylethane;1-Phenylethyl azide;methyl benzyl azide;(1-azidoethyl)benzene;rac-(1-azidoethyl)benzene;

Chemical Property of 1-Azidoethylbenzene

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 49.75000
• Density: g/cm³
• LogP: 2.51066

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Azidoethylbenzene

There total 33 articles about 1-Azidoethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(1-bromoethyl)benzne (585-71-7,38661-81-3) → 1-azidoethylbenzene (32366-25-9)

Guidance literature:

With sodium azide; In dimethyl sulfoxide; Inert atmosphere;

DOI:10.1039/c6nj02089e

Reference yield: 98.0%

(1-chloroethyl)benzene (672-65-1) → 1-azidoethylbenzene (32366-25-9)

Guidance literature:

With sodium azide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; at 20 ℃; for 50h; Inert atmosphere;

DOI:10.1002/chem.200903484

Reference yield: 93.0%

2-(1-phenylethoxy)-tetrahydro-2H-pyran (105966-39-0) → 1-azidoethylbenzene (32366-25-9)

Guidance literature:

With tetrabutylammoniun azide; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In acetonitrile; for 21.5h; Heating;

DOI:10.1080/104265090884292

upstream raw materials:

styrene

ethylbenzene

(1-chloroethyl)benzene

trimethylsilylazide

Downstream raw materials:

rac-methylbenzylamine

(R)-α-methylbenzyl azide

(S)-α-azidoethylbenzene

α-Phenethylcarbamidsaeureethylester

Refernces

• 1、 De Graaf, Albert J.,Mastrobattista, Enrico,Van Nostrum, Cornelus F.,Rijkers, Dirk T. S.,Hennink, Wim E.,Vermonden, Tina. "ATRP, subsequent azide substitution and 'click' chemistry: Three reactions using one catalyst in one pot". . p. 6972 - 6974. Retrieved 2011.
• 2、 Bui, Tien Tan,Kim, Hee-Kwon. "Facile Direct Coupling Reactions of MOM-protected Benzylic Alcohols Using Aluminum Chloride". supporting information. p. 1195 - 1198. Retrieved 2021/08/03.
• 3、 Zhong, Ying,Xu, Xiaoming,Xing, Qingzhao,Yang, Song,Gou, Jing,Gao, Ziwei,Yu, Binxun. "Furfuryl Cation Induced Three-Component Reaction to Synthesize Triazole-Substituted Thioesters". supporting information. p. 3251 - 3256. Retrieved 2020/05/25.