Journal of Antibiotics p. 1265 - 1271 (2000)
Update date:2022-08-17
Topics:
Sakuda
Ono
Ikeda
Nakamura
Inagaki
Kawachi
Nakayama
Suzuki
Isogai
Nagasawa
Blasticidin A, an antibiotic, showed strong inhibitory activity toward aflatoxin production by Aspergillus parasiticus. Its structure was characterized by NMR and chemical degradation experiments as 1, which is a tetramic acid derivative with a highly oxygenated long alkyl chain similar to aflastatin A (2). Absolute configurations of the eight chiral centers at C-4, 6, 31, 32, 33, 34, 35 and 37 of 1 were chemically determined. Blasticidin A almost completely inhibited aflatoxin production at 0.5 μm.
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