European Journal of Medicinal Chemistry p. 919 - 925 (1996)
Update date:2022-08-16
Topics:
Borgna
Carmellino
Natangelo
Pagani
Pastoni
Pregnolato
Terreni
N-Hydroxyalkyl derivatives of 1,2-benzisothiazol-3(2H)-one and 1,2-benzisothiazol-3(2H)-thione have been prepared and their antifungal and antibacterial activity evaluated. Several compounds were active against selected fungi and Gram-positive microorganisms. Interesting activity was observed against the anaerobic strain Clostridium perfringens. Generally the more active compounds belong to the class of 1,2-benzisothiazol-3(2H)-ones. The retardation matches R(M) of the compounds was also evaluated but the results obtained show that lipophilicity has only a minor effect on the antimicrobial activity.
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