Bioconjugate Chemistry
Page 24 of 27
1
2
3
4
5
6
7
8
9
21.
22.
23.
24.
25.
Piazza, A., Boule, J. B., Lopes, J., Mingo, K., Largy, E., Teulade-Fichou, M. P., and Nicolas, A. (2010)
Genetic instability triggered by G-quadruplex interacting Phen-DC compounds in Saccharomyces
cerevisiae, Nucleic Acids Res. 38, 4337-4348.
Lopes, J., Piazza, A., Bermejo, R., Kriegsman, B., Colosio, A., Teulade-Fichou, M. P., Foiani, M., and
Nicolas, A. (2011) G-quadruplex-induced instability during leading-strand replication, EMBO J. 30,
4033-4046.
Piazza, A., Adrian, M., Samazan, F., Heddi, B., Hamon, F., Serero, A., Lopes, J., Teulade-Fichou, M. P.,
Phan, A. T., and Nicolas, A. (2015) Short loop length and high thermal stability determine genomic
instability induced by G-quadruplex-forming minisatellites, EMBO J. 34, 1718-1734.
Pennarun, G., Granotier, C., Hoffschir, F., Mandine, E., Biard, D., Gauthier, L. R., and Boussin, F. D.
(2008) Role of ATM in the telomere response to the G-quadruplex ligand 360A, Nucleic Acids Res.
36, 1741-1754.
Pennarun, G., Granotier, C., Gauthier, L. R., Gomez, D., Hoffschir, F., Mandine, E., Riou, J. F.,
Mergny, J. L., Mailliet, P., and Boussin, F. D. (2005) Apoptosis related to telomere instability and cell
cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands,
Oncogene 24, 2917-2928.
Rodriguez, R., Müller, S., Yeoman, J. A., Trentesaux, C., Riou, J. F., and Balasubramanian, S. (2008) A
novel small molecule that alters shelterin integrity and triggers a DNA-damage response at
telomeres, J. Am. Chem. Soc. 130, 15758-15759.
Salvati, E., Leonetti, C., Rizzo, A., Scarsella, M., Mottolese, M., Galati, R., Sperduti, I., Stevens, M. F.,
D'Incalci, M., Blasco, M., Chiorino, G., Bauwens, S., Horard, B., Gilson, E., Stoppacciaro, A., Zupi, G.,
and Biroccio, A. (2007) Telomere damage induced by the G-quadruplex ligand RHPS4 has an
antitumor effect, J. Clin. Invest. 117, 3236-3247.
Balasubramanian, S., Hurley, L. H., and Neidle, S. (2011) Targeting G-quadruplexes in gene
promoters: a novel anticancer strategy?, Nat. Rev. Drug Discov. 10, 261-275.
Hurley, L. H., Von Hoff, D. D., Siddiqui-Jain, A., and Yang, D. (2006) Drug targeting of the c-MYC
promoter to repress gene expression via a G-quadruplex silencer element, Semin. Oncol. 33, 498-
512.
Boddupally, P. V., Hahn, S., Beman, C., De, B., Brooks, T. A., Gokhale, V., and Hurley, L. H. (2012)
Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-
piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC
promoter, J. Med. Chem. 55, 6076-6086.
Neidle, S. (2010) Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as
therapeutic targets in human cancer, FEBS J. 277, 1118-1125.
Duan, W., Rangan, A., Vankayalapati, H., Kim, M. Y., Zeng, Q., Sun, D., Han, H., Fedoroff, O. Y.,
Nishioka, D., Rha, S. Y., Izbicka, E., Von Hoff, D. D., and Hurley, L. H. (2001) Design and synthesis of
fluoroquinophenoxazines that interact with human telomeric G-quadruplexes and their biological
effects, Mol. Cancer Ther. 1, 103-120.
Lavrado, J., Brito, H., Borralho, P. M., Ohnmacht, S. A., Kim, N. S., Leitao, C., Pisco, S., Gunaratnam,
M., Rodrigues, C. M., Moreira, R., Neidle, S., and Paulo, A. (2015) KRAS oncogene repression in
colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines, Sci. Rep. 5, 9696.
Leonetti, C., Scarsella, M., Riggio, G., Rizzo, A., Salvati, E., D'Incalci, M., Staszewsky, L., Frapolli, R.,
Stevens, M. F., Stoppacciaro, A., Mottolese, M., Antoniani, B., Gilson, E., Zupi, G., and Biroccio, A.
(2008) G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in
preclinical models of solid tumors, Clin. Cancer Res. 14, 7284-7291.
Berardinelli, F., Sgura, A., Di Masi, A., Leone, S., Cirrone, G. A., Romano, F., Tanzarella, C., and
Antoccia, A. (2014) Radiation-induced telomere length variations in normal and in Nijmegen
Breakage Syndrome cells, Int. J. Radiat. Biol. 90, 45-52.
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
26.
27.
28.
29.
30.
31.
32.
33.
34.
35.
36.
Merle, P., Evrard, B., Petitjean, A., Lehn, J. M., Teulade-Fichou, M. P., Chautard, E., De Cian, A.,
Guittat, L., Tran, P. L., Mergny, J. L., Verrelle, P., and Tchirkov, A. (2011) Telomere targeting with a
new G4 ligand enhances radiation-induced killing of human glioblastoma cells, Mol. Cancer Ther.
10, 1784-1795.
37.
Merle, P., Gueugneau, M., Teulade-Fichou, M. P., Müller-Barthélémy, M., Amiard, S., Chautard, E.,
Guetta, C., Dedieu, V., Communal, Y., Mergny, J. L., Gallego, M., White, C., Verrelle, P., and
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