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Organic & Biomolecular Chemistry
Page 4 of 5
COMMUNICATION
Journal Name
compound 5 strongly binds with AChE active site and it has good
potential to show AchE inhibition activity.
DOI: 10.1039/D0OB00323A
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Conclusions
In conclusion, we demonstrated that usingAgNO3-TBHP
quinones, could be amidoalkylated with cheap and readily available
alkyl amide derivatives. This is the first report for the synthesis of
variety of amidoalkylated quinones. This alkylation procedure works
on variety of quinones under simple reaction condition. No pre-
functionalisation of starting material is required and only non-
hazardous reagents are used. The radical mechanism involved in
amidoalkylation reaction was confirmed with the aid of radical
scavenger. Importance of this process is highlighted by the synthesis
of different biologically active quinone analogues and
amidoalkylated phenothiazine-5-one derivative. Molecular docking
study revealed that compound 5 strongly binds with Alzheimer’s
disease (AD) associated AChE target site. Furthermore, synthetic
applications and biological studies of amidoalkylated quinone are
being carried out and results will be communicated separately.
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Conflicts of interest
There are no conflicts to declare.
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Acknowledgements
S.P and A.K.T.P. thanks UGC-RFSMS, New Delhi for the award of the
fellowship. We thank M.Sc., project students Ms. Jalani and Mr.
Sanjeevkumar for experimental help. We thank DST-FIST and DST-
PURSE New Delhi, India for NMR and HRMS facilities at School of
Chemistry, Bharathidasan University, HPC facility under
theDSTPURSE scheme(SR/FT/LS-113/2009). Tiruchirappalli, India.
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