MedChemComm p. 72 - 79 (2019)
Update date:2022-08-11
Topics:
Sankara Rao
Nagesh, Narayana
Lakshma Nayak
Sunkari, Satish
Tokala, Ramya
Kiranmai, Gaddam
Regur, Phanindranath
Shankaraiah, Nagula
Kamal, Ahmed
A new series of different naphthalimide-benzothiazole/cinnamide derivatives were designed, synthesized and tested for their in vitro cytotoxicity on selected human cancer cell lines. Among them, derivatives 4a and 4b with the 6-aminobenzothiazole ring and 5g with the cinnamide ring displayed potent cytotoxic activity against colon (IC50: 3.715 and 3.467 μM) and lung cancer (IC50: 4.074 and 3.890 μM) cell lines when compared to amonafide (IC50: 5.459 and 7.762 μM). Later, the DNA binding studies for these selected derivatives (by CD, UV/vis, fluorescence spectroscopy, DNA viscosity, and molecular docking) suggested that these new derivatives significantly intercalate between two strands of DNA. In addition, the most potent derivatives 4a and 4b were also found to inhibit DNA topoisomerase-II.
View MoreContact:13120882795;+86-21-34621078;+86-021-31122318
Address:Suite 2,No.2715 Longwu Road
Contact:86-531-67875205
Address:No.9-2,South of Shanda Road, Jinan ,China
Huludao Tianqi Shengye Chemical Co.,Ltd.
Contact:0086 429 2075777
Address:Area B,Shipbuilding Industry Park,Beigang District,Huludao City,Liaoning prov.,China
Changde Yungang Biotechnology Co., Ltd
website:http://www.cdyg.com
Contact:+86-736-7391178
Address:Qiaonan Industrial Park, Changde City, Hunan Province
Contact:0512-62706911
Address:No.289 Yinzhong South Road Wuzhong Economic Development District,Suzhou,China
Doi:10.1021/ac60076a029
(1953)Doi:10.1002/aoc.1773
(2011)Doi:10.1055/s-2004-829084
(2004)Doi:10.1081/SCC-120027720
(2004)Doi:10.1007/BF02494358
(1997)Doi:10.1021/bm901371p
(2010)