Tetrahedron Letters p. 2567 - 2570 (1982)
Update date:2022-08-29
Topics:
Caruso, Andrew J.
Polonsky, Judith
Rodriguez, Bertha Soto
Inactive chaparrin 1 has been converted in seven steps and 16 percent overall yield to castelanone 3 which is known to inhibit significantly growth of the murine lymphocytic leukemia P-388 cell line.The methodology developed has been applied to the preparation of quassinoid analogs 15, 16 and 17.
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