J Biol Inorg Chem
16. Hancock CN, Stockwin LH, Han B, Divelbiss RD, Jun JH, Mal-
hotra SV, Hollingshead MG, Newton DL (2011) Free Rad Biol
Med 2011, 50(1) 110-121
copper–thiosemicarbazones are used as the principal reac-
tive oxygen generating agents is the subject of current
investigations.
17. Stefani C, El-Eisawi Z, Jansson PJ, Kalinowski DS, Richardson
DR (2015) J Inorg Biochem 152:20–37
Acknowledgements We wish to acknowledge the contribution of
Dr Gregg Maynard for assistance in setting up flow cytometry stud-
ies. F Akladios acknowledges the receipt of an Australian Postgradu-
ate Award (APA). CJP wishes to thank the CSU Pharmacy Founda-
tion for a grant partially funding this study. CJP and SDA thank the
Kolling Institute (Royal North Shore Hospital) for the donation and
characterization of the MCF-7 cell line employed in this study and Dr
N Proschogo (University of Sydney) for the provision of mass spec-
trometry expertise.
18. Giles GI (2006) Curr Pharm Design 12(34):4427–4443
19. Tew KD, Townsend DM (2011) Curr Opin Chem Biol
15(1):156–161
20. Kalinina E, Chernov N, Saprin A (2008) Biochemistry- Moscow
73(13):1493–1510
21. Nolan KA, Zhao H, Faulder PF, Frenkel AD, Timson DJ, Siegel
D, Ross D, Burke TR Jr, Stratford IJ, Bryce RA (2007) J Med
Chem 50(25):6316–6325
22. Li R, Bianchet MA, Talalay P, Amzel LM (1995) Proc Natl Acad
Sci USA 92(19):8846–8850
23. Van Rensburg C, Van Staden A, Anderson R (1993) Cancer Res
53(2):318–323
24. Van Rensburg C, Anderson R, O’Sullivan J (1997) Crit Rev
Oncol Hemat 25(1):55–67
References
1. Peña MO, Lee J, Thiele DJ (1999) J Nutr 129(7):1251–1260
2. Evans GW (1973) Physiol Rev 53(3):535–570
3. Kouremenou-Dona E, Dona A, Papoutsis J, Spiliopoulou C
(2006) Sci Total Environ 359(1–3):76–81
25. Akladios FN, Andrew SD, Parkinson CJ (2015) Bioorg. Med.
Chem. 23:3097–3104
26. Crossley ML, Turner RJ, Hofmann CM, Dreisbach PF, Parker
RP (1952) J Am Chem Soc 74(3):578–584
4. Kuo HW, Chen SF, Wu CC, Chen DR, Lee JH (2002) Biol Trace
Elem Res 89:1–11
5. Gupte A, Mumper RJ (2009) Cancer Treat Rev 35(1):32–46
6. Gupta SK, Shukla VK, Vaidya MP, Roy SK, Gupta S (1991) J
Surg Oncol 46:178–181
7. Buettner GR, Jurkiewicz BA (1996) Radiat Res 145:532–541
8. Schumaker PT (2006) Cancer Cell 10(3):175–176
9. Ma B, Goh BC, Tan EH, Lam KC, Soo R, Leong SS, Wang LZ,
Mo F, Chan AT (2008) Investig New Drug 26(2):169–173
10. Kalinowski DS, Richardson DR (2005) Pharmacol Rev
57(4):547–583
11. Whitnall M, Howard J, Ponka P, Richardson DR (2006) Proc
Natl Acad Sci USA 103(40):14901–14906
12. Jansson PJ, Sharpe PC, Bernhardt PV, Richardson DR (2010) J
Med Chem 53(15):5759–5769
13. Lovejoy DB, Jansson PJ, Brunk U, Wong J, Ponka P, Richardson
DR (2011) Cancer Res 71(17):5871–5880
14. Kalinowski DS, Jansson PJ, Kovacevic Z, Richardson DR (2013)
Redox Rep 18(2):48–50
27. Kalinowski DS, Yu Y, Sharpe PC, Islam M, Liao Y-T, Lovejoy
DB, Kumar N, Bernhardt PV, Richardson DR (2007) J Med
Chem 50(15):3716–3729
28. Richardson DR, Sharpe PC, Lovejoy DB, Senaratne D,
Kalinowski DS, Islam M, Bernhardt PV (2006) J Med Chem
49(22):6510–6521
29. Lovejoy DB, Richardson DR (2002) Blood 100(2):666–676
30. Brown CA, West DX (2003) Transit Metal Chem 28(2):154–159
31. Chou T-C (2010) Cancer Res 70(2):440–446
32. Tütem E, Apak R, Baykut F (1991) Analyst 116:89–94
33. Cobine PA, Pierrel F, Bestwick ML, Winge DR (2006) J Biol
Chem 281:36552–36559
34. Samuni Y, Goldstein S, Dean OM, Berk M (2013) Biochim Bio-
phys Acta 1830:4117–4129
35. Zheng J, Lou JR, Benbrook DM, Hanigan MH, Lind SE, Ding
W-Q (2010) Cancer Lett 298:186–194
36. Saito M, Kobayashi M, Iwabuchi S, Morita Y, Takamura Y,
Tamiya E (2004) J Biochem 136(6):813–823
37. Wlodkowic D, Skommer J, Darzynkiewicz Z (2009) Methods
15. Gaál A, Orgován G, Polgári Z, Réti A, Mihucz VG, Bősze S,
Szoboszlai N, Streli C (2014) J Inorg Biochem 130:52–58
1 3