NJC
Paper
11 L. Griffe, M. Poupot, P. Marchand, A. Maraval, C. O. Turrin,
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Statistical analysis
The experimental data were evaluated from one-way analysis of
variance (ANOVA) statistical method. The value of 0.05 was
selected as the statistical significance level and the data were
indicated with (*) for p o 0.05, (**) for p o 0.01, and (***) for
p o 0.001.
12 S. Pektas-, S. Bilge Koçak, N. S. Bas-terzi, Z. Kılıç, C. T. Zeyrek,
¨
B. Coban and O. Çelik, Inorg. Chim. Acta, 2018, 47, 51–65.
13 P. Gomulak, B. Klajnert, M. Bryszewska, J. P. Majoral,
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Conclusions
14 N. El Brahmi, S. El Kazzouli, S. M. Mignani, E. M. Essassi,
G. Aubert, R. Laurent, A. M. Caminade, M. M. Bousmina,
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15 J. Y. Yu, Y. J. Jun, S. H. Jang, H. J. Lee and Y. S. Sohn, J. Inorg.
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16 T. Wasiak, M. Marcinkowska, I. Pieszynski, M. Zablocka,
A. M. Caminade, J. P. Majoral and B. K. Maculewicz, New
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17 T. Wasiak, M. Ionov, K. Nieznanski, H. Nieznanska,
O. Klementieva, M. Granell, J. Cladera, J. P. Majoral, A. M.
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18 R. Kagit, M. Yildirim, O. Ozay, S. Yesilot and H. Ozay, Inorg.
Chem., 2014, 53, 2144–2151.
In summary, three novel coumarin–phosphazene derivatives
(2a–2c) were designed and synthesized and their anticancer
activities were evaluated in vitro by CCK-8 assays. The results
showed that these active molecules have moderate antitumor
activities against the MCF-7 and 4T1 cell lines when coumarin
was introduced onto the cyclotriphosphazene backbone. The
results obviously suggested that 2a–2c with various coumarin
moieties attached onto cyclotriphosphazenes enhanced anti-
cancer activity, which showed that cyclotriphosphazenes play
an important role in mediating antitumor activities. The results
prompted us to construct new active molecules based on
cyclotriphosphazenes for different biomedical applications.
19 N. El Brahmi, S. M. Mignani, J. Caron, S. El Kazzouli,
M. M. Bousmina, A. M. Caminade, T. Cresteil and J. P.
Majoral, Nanoscale, 2015, 7, 3915–3922.
Conflicts of interest
There are no conflicts to declare.
20 F. Hayat, E. Moseley, A. Salahuddin, R. L. Van Zyl and
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Acknowledgements
We would like to thank the Shanghai Education Commission
through the Shanghai Leading Talents Program (ZX201903000002)
and the Sino-French Cai Yuanpei Program.
¨
¨
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