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Cas Database

Name	Guaiacol glycidyl ether	EINECS	218-644-8
CAS No.	2210-74-4	Density	1.142 g/cm³
PSA	30.99000	LogP	1.47280
Solubility	4.21g/L at 20℃	Melting Point	33-36 °C
Formula	C₁₀H₁₂O₃	Boiling Point	265.3 °C at 760 mmHg
Molecular Weight	180.203	Flash Point	87.4 °C
Transport Information	N/A	Appearance	White crystalline solid
Safety		Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	Benzene,1-(2,3-epoxypropoxy)-2-methoxy- (6CI,7CI,8CI);Oxirane,[(2-methoxyphenoxy)methyl]- (9CI);1,2-Epoxy-3-(2-methoxyphenoxy)propane;1,2-Epoxy-3-(o-methoxyphenoxy)propane;1-(2-Methoxyphenoxy)-2,3-epoxypropane;2-(2,3-Epoxypropoxy)anisole;2-Methoxy-1-(oxiranylmethoxy)benzene;2-Methoxyphenyl glycidyl ether;2-[(2-Methoxyphenoxy)methyl]oxirane;Glycidyl2-methoxyphenyl ether;NSC 112256;NSC 133442;	Article Data	49

Guaiacol glycidyl ether Synthetic route

: 13052-77-2
sodium 2-methoxyphenolate

: 106-89-8
epichlorohydrin

: 2210-74-4
2-(2-methoxy-phenoxymethyl)-oxirane

Conditions

Conditions	Yield
at 20℃; for 24h;	95%

: 90-05-1
2-methoxy-phenol

: 106-89-8
epichlorohydrin

: 2210-74-4
2-(2-methoxy-phenoxymethyl)-oxirane

Conditions

Conditions	Yield
Stage #1: 2-methoxy-phenol With sodium hydroxide In water at 30℃; Large scale; Stage #2: epichlorohydrin In water at 25 - 35℃; Large scale;	94%
With potassium carbonate at 120℃; for 4.5h;	93%
With n-Bu4NOSO2OCH2CHOHCH3; potassium carbonate at 75 - 80℃; for 1h;	90%

: 90-05-1
2-methoxy-phenol

: 3132-64-7
1,2-Epoxy-3-bromopropane

: 2210-74-4
2-(2-methoxy-phenoxymethyl)-oxirane

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran Heating;	82%
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 6h;	62%
With base
With potassium carbonate In butanone at 80℃;

: 90-05-1
2-methoxy-phenol

: 106-89-8
epichlorohydrin

A: 25772-81-0
1-chloro-3-(2-methoxyphenoxy)-2-propyl alcohol

B: 2210-74-4
2-(2-methoxy-phenoxymethyl)-oxirane

Conditions

Conditions	Yield
With sodium hydroxide In water for 7h; Heating;	A 23% B 68%
With sodium hydroxide In 1,4-dioxane; water at 25 - 30℃;
With sodium hydroxide at 25 - 30℃;

: 79-21-0
peracetic acid

: 4125-43-3
O-allyl guaiacol

: 2210-74-4
2-(2-methoxy-phenoxymethyl)-oxirane

Conditions

Conditions	Yield
With diethyl ether

: 96-23-1
1,3-Dichloro-2-propanol

: 90-05-1
2-methoxy-phenol

: 2210-74-4
2-(2-methoxy-phenoxymethyl)-oxirane

Conditions

Conditions	Yield
With sodium hydroxide
With sodium hydroxide

: 13052-77-2
sodium guaiacolate

: 106-89-8
epichlorohydrin

: 2210-74-4
2-(2-methoxy-phenoxymethyl)-oxirane

Conditions

Conditions	Yield
tris-(3,6-dioxa-octyl)amine In acetonitrile

: 90-05-1
2-methoxy-phenol

: 106-89-8
epichlorohydrin

A: 16929-60-5
1,3-bis(2-methoxyphenoxy)propan-2-ol

B: 2210-74-4
2-(2-methoxy-phenoxymethyl)-oxirane

Conditions

Conditions	Yield
Stage #1: 2-methoxy-phenol With sodium hydroxide; tetrabutylammomium bromide In water; toluene at 25 - 30℃; for 0.5h; Stage #2: epichlorohydrin In water; toluene at 35 - 40℃; for 6h; Product distribution / selectivity;
With sodium hydroxide at 10 - 15℃; Temperature;

: 90-05-1
2-methoxy-phenol

: 106-89-8
epichlorohydrin

A: 25772-81-0
1-chloro-3-(2-methoxyphenoxy)-2-propyl alcohol

B: 16929-60-5
1,3-bis(2-methoxyphenoxy)propan-2-ol

C: 93-14-1
guaifenesin

D: 2210-74-4
2-(2-methoxy-phenoxymethyl)-oxirane

Conditions

Conditions	Yield
With sodium hydroxide In toluene at 25 - 30℃; Solvent; Concentration;

...Expand

: 110-89-4
piperidine

: 75-15-0
carbon disulfide

: 2210-74-4
2-(2-methoxy-phenoxymethyl)-oxirane

: C16H23O3NS2

Conditions

Conditions	Yield
at 20℃;	99%

Guaiacol glycidyl ether Chemical Properties

IUPAC Name: 2-[(2-Methoxyphenoxy)methyl]oxirane
Following is the structure of Oxirane,2-[(2-methoxyphenoxy)methyl]- (CAS NO.2210-74-4):

Empirical Formula: C₁₀H₁₂O₃
Molecular Weight: 180.2005
EINECS: 218-644-8
Index of Refraction: 1.526
Molar Refractivity: 48.45 cm³
Molar Volume: 157.7 cm³
Density: 1.142 g/cm³
Flash Point: 87.4 °C
Melting point: 33-36 °C
Polarizability: 19.2 10^-24cm³
Surface Tension: 40.4 dyne/cm
Enthalpy of Vaporization: 48.29 kJ/mol
Boiling Point: 265.3 °C at 760 mmHg
Vapour Pressure: 0.0152 mmHg at 25 °C
Appearance of Oxirane,2-[(2-methoxyphenoxy)methyl]- (CAS NO.2210-74-4): White Crystalline Solid
Product Categories: INTERMEDIATESOFRANOLAZINE; API intermediates; Various Intermediates; Intermediates; Intermediates & Fine Chemicals; Pharmaceuticals; Ranolazine
Canonical SMILES: COC1=CC=CC=C1OCC2CO2
InChI: InChI=1S/C10H12O3/c1-11-9-4-2-3-5-10(9)13-7-8-6-12-8/h2-5,8H,6-7H2,1H3
InChIKey: RJNVSQLNEALZLC-UHFFFAOYSA-N

Guaiacol glycidyl ether Uses

Oxirane,2-[(2-methoxyphenoxy)methyl]- (CAS NO.2210-74-4) can be used as Ranolazine intermediate.

Guaiacol glycidyl ether Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	subcutaneous	1355mg/kg (1355mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 1355, 1965.

Guaiacol glycidyl ether Specification

Oxirane,2-[(2-methoxyphenoxy)methyl]- , its cas register number 2210-74-4. It also can be called 1,2-Epoxy-3-(o-methoxyphenoxy)propane ; Guajacol-glycidaether ; Guajacol-glycidaether [German] ; NSC 112256 ; NSC 133442 ; and Propane, 1,2-epoxy-3-(o-methoxyphenoxy)- .

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