Product Name: Neuromedin B (CAS NO.87096-84-2)

Molecular Formula: C₅₂H₇₃N₁₅O₁₂S
Molecular Weight: 1132.29432g/mol
Mol File: 87096-84-2.mol
Boiling point: 980.3 °C
Storage Temperature: −20°C
Flash Point: 980.3 °C
Density: 1.337 g/cm³
Surface Tension: 64 dyne/cm
Enthalpy of Vaporization: 282.09 kJ/mol
Vapour Pressure:
XLogP3-AA: -1.6
H-Bond Donor: 15
Product Categories: Peptide; BombesinsCancer Research; Neuropeptides; Peptides for Cell Biology; Tumor Growth Regulation; Tumor Promotors; Neuromedins and related

 Neuromedin B (CAS NO.87096-84-2) acts by binding to its high affinity cell surface receptor, neuromedin B receptor (NMBR). This receptor is a G protein-coupled receptor with seven transmembrane spanning regions, hence the receptor is also denoted as a 7-transmembrane receptor (7-TMR). Upon binding several intracellular signaling pathways are triggered (see Figure 2).
When Neuromedin B (CAS NO.87096-84-2) binds to its 7-TMR, the heterotrimeric G protein that is attached to the receptor is activated. The G-protein is called heterotrimeric because it consists of 3 polypeptides: α subunit, β subunit, and γ subunit. In the activated NMBR/G-protein complex, there occurs an exchange of GTP for GDP bound to G-α subunit. The G-α subunit, in turn, dissociated form the G-βγ subunits. The free G-α iactivates adenylate cyclase (AC), which, in turn, catalyzes the conversion of ATP to cAMP, the latter of which functioning as a second messenger. cAMP activates of the enzyme Protein Kinase A (PKA). PKA enters the nucleus and activates the cAMP response element-binding protein. The activated CREB binds along with CREB binding protein, co-activator to the CRE region of the DNA in the nucleus. CREB and CBP are held together by leucine zippers. CRE is the control that activates number of growth factors, and thus cell proliferation and some anti-apoptotic genes. In the brain, CREB plays a role in long-term memory and learning.

 Neuromedin B ,its CAS NO. is 87096-84-2,the synonyms is Gly-asn-leu-trp-ala-thr-gly-his-phe-met-NH2 ; Glycyl-arginyl-leucyl-tryptophyl-alanyl-threonyl-glycyl-histidyl-phenylalanyl-methioninamide ; Neuromedin B (swine spinal cord) ; Ranatensin, 1-glycine-2-L-asparagine-3-L-leucine-4-de-L-glutamine-7-L-threonine- .