Basic Information | Post buying leads | Suppliers |
Name |
Nicotine Sulfate |
EINECS | 200-606-7 |
CAS No. | 65-30-5 | Density | 1.22 |
PSA | 115.24000 | LogP | 4.00040 |
Solubility | Soluble in water | Melting Point |
N/A |
Formula | C20H26N4•O4S | Boiling Point | 244.4 °C at 760 mmHg |
Molecular Weight | 418.56 | Flash Point | 101.7 °C |
Transport Information | UN 1658 6 | Appearance | brown Viscous liquid |
Safety | Poison by ingestion and skin contact. When heated to decomposition it emits very toxic fumes of SOx and organic fumes. See also NICOTINE and SULFATES. | Risk Codes | 24/25-26-36/37/38-63 |
Molecular Structure | Hazard Symbols | T+ | |
Synonyms |
(s)-3-(1-methyl-2-pyrrolidinyl)pyridinesulfate(2:1);1-methyl-2-(3-pyridyl)-pyrrolidinsulfate;3-(1-methyl-2-pyrrolidinyl)-pyridin(s)-pyridinsulfate(2:1);ai3-02435;caswellno.597a;ent2,435;epapesticidechemicalcode056703;l-1-methyl-2-(3-pyridyl)-pyrrolidinesulfate |
S-(-)-nicotine hemisulfate
4-(6-hydroxy-[3]pyridyl)-4-oxo-butyric acid
Conditions | Yield |
---|---|
With Pseudomonas sp. DSM 8653; citric acid; yeast extract In water at 30℃; for 15h; | 91% |
S-(-)-nicotine hemisulfate
(S)-6-hydroxy-D-nicotine
Conditions | Yield |
---|---|
With Arthrobacter oxydans NRRL-B-3603; corn steep liquor In water at 30℃; for 38h; pH 5.5; | 51% |
S-(-)-nicotine hemisulfate
(S)-5,6-dichloronicotine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 51 percent / Arthrobacter oxydans NRRL-B-3603, corn steep liquor / H2O / 38 h / 30 °C / pH 5.5 2: 91 percent / chlorine / methanol / 5 h / 19 °C 3: 70 percent / PCl5 / POCl3 / 1 h / 50 - 95 °C View Scheme |
S-(-)-nicotine hemisulfate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 51 percent / Arthrobacter oxydans NRRL-B-3603, corn steep liquor / H2O / 38 h / 30 °C / pH 5.5 2: 91 percent / chlorine / methanol / 5 h / 19 °C View Scheme |
S-(-)-nicotine hemisulfate
(S)-6-chloronicotine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 51 percent / Arthrobacter oxydans NRRL-B-3603, corn steep liquor / H2O / 38 h / 30 °C / pH 5.5 2: 88.6 percent / PCl5 / POCl3 / 1 h / 40 - 92 °C View Scheme |
Conditions | Yield |
---|---|
In ethanol; water pptn. with abs. alcohol; | |
In ethanol; water pptn. with abs. alcohol; |
Conditions | Yield |
---|---|
In water addn. of a few drops of aq. soln. of NiSO4*6H2O and NH4SCN to aq. soln. of tech. nicotinium sulfate (40% nicotine);; pptn.;; | |
In water addn. of a few drops of aq. soln. of NiSO4*6H2O and NH4SCN to aq. soln. of tech. nicotinium sulfate (40% nicotine);; pptn.;; |
Conditions | Yield |
---|---|
With water In ethanol; water mixing of an aq. soln. of CuSO4 and a soln. of neutral nicotinium sulfate in abs. ethanol;; pptn. by further addn. of abs. ethanol; sepn. after a few hours; washing with 95% ethanol; drying on air;; | >99 |
With H2O In ethanol; water mixing of an aq. soln. of CuSO4 and a soln. of neutral nicotinium sulfate in abs. ethanol;; pptn. by further addn. of abs. ethanol; sepn. after a few hours; washing with 95% ethanol; drying on air;; | >99 |
Conditions | Yield |
---|---|
In ethanol; water addn. of abs. ethanol to mixt. of 0.03 mol NiSO4 in H2O and 0.04 mol neutral nicotinium sulfate in abs. ethanol, concg.;; pptn., washing with 95% ethanol and drying in air;; | |
In ethanol; water addn. of abs. ethanol to mixt. of 0.03 mol NiSO4 in H2O and 0.04 mol neutral nicotinium sulfate in abs. ethanol, concg.;; pptn., washing with 95% ethanol and drying in air;; |
Chemistry informtion about Nicotine Sulfate (CAS NO.65-30-5) is:
IUPAC Name: 3-(1-Methylpyrrolidin-2-Yl)Pyridine ; Sulfuric Acid
Synonyms: (S)-3-(1-Methyl-2-Pyrrolidinyl)Pyridinesulfate(2:1) ; 1-Methyl-2-(3-Pyridyl)-Pyrrolidinsulfate ; 3-(1-Methyl-2-Pyrrolidinyl)-Pyridin(S)-Pyridinsulfate(2:1) ; Ai3-02435 ; Caswellno.597a ; Ent2,435 ; Epapesticidechemicalcode056703 ; L-1-Methyl-2-(3-Pyridyl)-Pyrrolidinesulfate
Product Categories: Alkaloids ; Biochemistry ; Pyridine Alkaloids
MF: C20H30N4O4S
MW: 422.54
EINECS: 200-606-7
Density: 1.22g/cm3
Flash Point: 101.7 °C
Boiling Point: 244.4 °C at 760 mmHg
Vapour Pressure: 0.0303 mmHg at 25°C
Enthalpy of Vaporization: 48.15 kJ/mol
Merck: 6524
Stability: Stable. Incompatible with strong oxidisers. Flammable.
Following is the molecular structure:
Nicotine Sulfate (CAS NO.65-30-5) has been used since the turn of the century and is the most hazardous botanical insecticide available to home gardeners. The insecticide is extracted from tobacco by steam distillation or solvent extraction.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
bird - wild | LD50 | oral | 32mg/kg (32mg/kg) | Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. | |
cat | LD50 | intraperitoneal | 20mg/kg (20mg/kg) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 86, 1982. | |
duck | LD50 | oral | 75mg/kg (75mg/kg) | Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. | |
mouse | LD50 | intraperitoneal | 10200ug/kg (10.2mg/kg) | Journal of Pharmacy and Pharmacology. Vol. 38, Pg. 54, 1986. | |
mouse | LD50 | oral | 8550ug/kg (8.55mg/kg) | Behavioral: tremor behavioral: muscle contraction or spasticity) lungs, thorax, or respiration: dyspnea | Hygiene and Sanitation Vol. 34(4-6), Pg. 187, 1969. |
pigeon | LD50 | oral | 75mg/kg (75mg/kg) | Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. | |
quail | LD50 | oral | 316mg/kg (316mg/kg) | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. | |
rabbit | LD50 | skin | 50mg/kg (50mg/kg) | "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971Vol. -, Pg. 141, 1971. | |
rat | LC50 | inhalation | 22mg/m3 (22mg/m3) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 86, 1982. | |
rat | LD50 | oral | 50mg/kg (50mg/kg) | Agricultural Research Service, USDA Information Memorandum. Vol. 20, Pg. 16, 1966. | |
rat | LD50 | skin | 285mg/kg (285mg/kg) | Behavioral: tremor behavioral: convulsions or effect on seizure threshold behavioral: excitement | Toxicology and Applied Pharmacology. Vol. 2, Pg. 88, 1960. |
rat | LD90 | intraperitoneal | 29mg/kg (29mg/kg) | Behavioral: altered sleep time (including change in righting reflex) behavioral: tremor behavioral: convulsions or effect on seizure threshold | Nutrition Reports International. Vol. 23, Pg. 43, 1981. |
EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.
S49:Keep only in the original container. Poison by ingestion and skin contact. When heated to decomposition it emits very toxic fumes of SOx and organic fumes. See also NICOTINE and SULFATES.
Hazard Codes:
T+
Risk Statements:
R24/25:Toxic in contact with skin and if swallowed.
R26:Very toxic by inhalation.
R36/37/38:Irritating to eyes, respiratory system and skin.
R63:Possible risk of harm to the unborn child.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S28:After contact with skin, wash immediately with plenty of soap-suds.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 1658 6.1/PG 2
RTECS: QS9625000
HazardClass: 6.1(a)
PackingGroup: II
DOT Classification: 6.1; Label: Poison
Nicotine Sulfate (CAS NO.65-30-5) is an clear colorless aqueous solution. It is toxic by inhalation and may be toxic by skin absorption.And it can produces toxic oxides of nitrogen during combustion. It is soluble in water.It arises from the neutralization of nicotine with sulfuric acid. Emits very toxic fumes of carbon monoxide and oxides of nitrogen when heated to decomposition [Lewis, 3rd ed., 1993, p. 919].It May react exothermically with strong oxidizing agents and strong reducing agents.You need to avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.Also, it is non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways.