- Nortropine
- Nortropine hydrochloride
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Cas Database |
| Name |
Nortropine |
EINECS | 238-356-6 |
| CAS No. | 538-09-0 | Density | 1.096 g/cm3 |
| PSA | 32.26000 | LogP | 0.59050 |
| Solubility | N/A | Melting Point |
108-110 °C |
| Formula | C7H13NO | Boiling Point | 266.5 °C at 760 mmHg |
| Molecular Weight | 127.186 | Flash Point | 115 °C |
| Transport Information | N/A | Appearance | light tan solid |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
1aH,5aH-Nortropan-3a-ol (8CI);8-Azabicyclo[3.2.1]octan-3-ol, endo-;Nortropine (6CI,7CI);3a-Nortropanol;N-Demethyltropine;NSC 72850;Nortropenol;Nortropin;Tropigenin;endo-8-Azabicyclo[3.2.1]octan-3-ol; |
Article Data | 26 |
Nortropine Synthetic route
| Conditions | Yield |
|---|---|
| With DAP(2+)*2BF4(1-); oxygen In acetonitrile at 20℃; Irradiation; | 87% |
| With DAP(2+)*2BF4(1-); oxygen In acetonitrile at 20℃; Product distribution; Irradiation; photochemical N-demethylation of var. tert. amines; | 87% |
| With sodium hydroxide; water; potassium hexacyanoferrate(III) |
| Conditions | Yield |
|---|---|
| iron In isopropyl alcohol at 60℃; for 2h; Product distribution / selectivity; | A 84% B 5% |
| Stage #1: tropine-N-oxide hydrochloride With ferrocene In chloroform for 24h; Reflux; Stage #2: With sodium hydroxide In chloroform; water | A 74% B 8% |
| Conditions | Yield |
|---|---|
| With hydrogen In methanol at 25 - 30℃; under 7500.75 Torr; for 24h; | 83% |
- 115522-42-4
(1R,3R,5S)-3-Benzyloxy-8-(toluene-4-sulfonyl)-8-aza-bicyclo[3.2.1]octane
- 538-09-0
nortropine
| Conditions | Yield |
|---|---|
| With sodium In ammonia | 81% |
- 120-29-6
3-tropanol
A
- 50626-97-6
(1R,3R,5S)-3-Hydroxy-8-aza-bicyclo[3.2.1]octane-8-carbaldehyde
B
- 538-09-0
nortropine
| Conditions | Yield |
|---|---|
| With oxygen; lithium perchlorate; 9,10-Dicyanoanthracene In acetonitrile at 20℃; Irradiation; | A 15% B 85 % Spectr. |
| With oxygen; 9,10-Dicyanoanthracene In acetonitrile at 20℃; Irradiation; | A 27 % Spectr. B 73 % Spectr. |
- 55727-40-7
(1R,3r,5S)-8-acetyl-8-azabicyclo[3.2.1]octan-3-yl acetate
- 7664-93-9
sulfuric acid
- 538-09-0
nortropine
- 538-09-0
nortropine
| Conditions | Yield |
|---|---|
| With potassium hydroxide |
- 538-09-0
nortropine
- 538-09-0
nortropine
| Conditions | Yield |
|---|---|
| With barium dihydroxide |
Nortropine Chemical Properties
Molecular structure of Nortropine (CAS NO.538-09-0):
Product Name: Nortropine
CAS Registry Number: 538-09-0
IUPAC Name: 8-Azabicyclo[3.2.1]octan-3-ol
Molecular Weight: 127.18422 g/mol
Molecular Formula: C7H13NO
XLogP3-AA: 0.3
H-Bond Donor: 2
H-Bond Acceptor: 2
Melting Point: 108-110 °C
Refractive Index: 1.52
Flash Point: 115 °C
Enthalpy of Vaporization: 58.58 kJ/mol
Boiling Point: 266.5 °C at 760 mmHg
Vapour Pressure: 0.00118 mmHg at 25 °C
Product Categories: pharmacetical; Trospium Chloride; Chiral Reagents; Intermediates & Fine Chemicals; Metabolites & Impurities; Pharmaceuticals
Nortropine Uses
Nortropine (CAS NO.538-09-0) can be used as a metabolite of Atropine.
Nortropine Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 180mg/kg (180mg/kg) | Annales de Chimie. Vol. 7, Pg. 537, 1962. | |
| mouse | LD50 | intravenous | 41mg/kg (41mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 145, Pg. 97, 1963. | |
| mouse | LD50 | oral | 1420mg/kg (1420mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 145, Pg. 97, 1963. | |
| rabbit | LD50 | intravenous | > 50mg/kg (50mg/kg) | Annales de Chimie. Vol. 7, Pg. 537, 1962. |
Nortropine Specification
Nortropine (CAS NO.538-09-0) also can be called 1alpha-H,5alpha-H-Nortropan-3alpha-ol ; NSC 72850 ; Nortropane, 3-hydroxy- ; Nortropenol ; Nortropidine, 2,3-dihydro-3-hydroxy- ; Nortropin ; Tropigenin ; Tropigenine ; 1-alpha-H,5-alpha-H-Nortropan-3-alpha-ol ; 1alphaH,5alphaH-Nortropan-3alpha-ol (8CI) ; 8-Azabicyclo(3.2.1)octan-3-ol, endo- (9CI) . It is a light tan solid.
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