- Oxacillin
- Oxacillin sodium monohydrate
- Oxacillin sodium salt
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Cas Database |
| Name |
Oxacillin |
EINECS | 200-635-5 |
| CAS No. | 66-79-5 | Density | 1.49±0.1 g/cm3(Predicted) |
| PSA | 138.04000 | LogP | 2.22410 |
| Solubility | Soluble | Melting Point |
188oC |
| Formula | C19H19 N3 O5 S | Boiling Point | 686.8±55.0 °C(Predicted) |
| Molecular Weight | 401.443 | Flash Point | N/A |
| Transport Information | N/A | Appearance | white to off white free flowing crystalline powder |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | UN NO. |
| Synonyms |
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-6-(5-methyl-3-phenyl-4-isoxazolecarboxamido)-7-oxo- (8CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-, [2S-(2a,5a,6b)]-; 5-Methyl-3-phenyl-4-isooxazolylpenicillin;5-Methyl-3-phenyl-4-isoxazolylpenicillin;6-(5-Methyl-3-phenyl-4-isoxazolyl)aminopenicillanic acid; MPI-penicillin;MPi-PC; Oxacillin; Oxazocillin; Oxazocilline; Penicillin,(5-methyl-3-phenyl-4-isoxazolyl)-; Prostaphlyn |
Article Data | 6 |
Oxacillin Chemical Properties
Chemistry informtion about Oxacillin (CAS NO.66-79-5) is:
IUPAC Name: (2S,5R,6R)-3,3-Dimethyl-6-[(5-Methyl-3-Phenyl-1,2-Oxazole-4-Carbonyl)Amino]-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid
Synonyms: Oxacillin ; [2s-(2,5,6)]-3,3-Dimethyl-6-(Methyl-3-Phenylisoxaz-4-Ole-Carboxamide-7-Oxy-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid ; (2s,5r,6r)-3,3-Dimethyl-6-[(5-Methyl-3-Phenylisoxazol-4-Yl)Carbonylamino]-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid ; Bactocil ; Oxazina ; Penstapho
MF: C19H19N3O5S
MW: 401.44
EINECS: 200-635-5
Density: 1.49 g/cm3
Flash Point: 369.2 °C
Boiling Point: 686.8 °C at 760 mmHg
Vapour Pressure: 8.32E-20 mmHg at 25°C
Enthalpy of Vaporization: 105.76 kJ/mol
Following is the molecular structure of Oxacillin (CAS NO.66-79-5) is:
Oxacillin Uses
Oxacillin (CAS NO.66-79-5) is effective against penicillinase enzymes.Also, it is widely used clinically in the US, but in the UK is only used for laboratory identification of resistant organisms.
Oxacillin Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | TDLo | intravenous | 2550mg/kg/17D (2550mg/kg) | blood: agranulocytosis | Journal of Pediatrics. Vol. 90, Pg. 668, 1977. |
| guinea pig | LD50 | unreported | 120mg/kg (120mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(9), Pg. 10, 1977. | |
| infant | TDLo | intravenous | 3800mg/kg/19D (3800mg/kg) | blood: agranulocytosis | Journal of Pediatrics. Vol. 89, Pg. 769, 1976. |
| man | TDLo | intravenous | 3800mg/kg/19D (3800mg/kg) | blood: agranulocytosis | Journal of Pediatrics. Vol. 89, Pg. 769, 1976. |
| mouse | LD50 | intravenous | 1490mg/kg (1490mg/kg) | Pharmaceutical Chemistry Journal Vol. 1, Pg. 245, 1967. | |
| mouse | LD50 | oral | 6500mg/kg (6500mg/kg) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 95, 1982. | |
| mouse | LD50 | unreported | 28gm/kg (28000mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(9), Pg. 10, 1977. | |
| rat | LD50 | unreported | 10gm/kg (10000mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(9), Pg. 10, 1977. | |
| women | TDLo | intravenous | 40mg/kg/7H-I (40mg/kg) | skin and appendages (skin): "dermatitis, other: after systemic exposure" | Annals of Pharmacotherpy. Vol. 33, Pg. 1060, 1999. |
| women | TDLo | intravenous | 5560mg/kg/20D (5560mg/kg) | blood: agranulocytosis | Southern Medical Journal. Vol. 70, Pg. 1245, 1977. |
| women | TDLo | oral | 200mg/kg/10D- (200mg/kg) | gastrointestinal: other changes | Southern Medical Journal. Vol. 77, Pg. 532, 1984. |
Oxacillin Safety Profile
Poison by an unspecified route. Moderately toxic by ingestion and intravenous routes. Human systemic effects: angranulocytosis. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also PENICILLIN; PENICILLIN compounded with CHOLINE CHLORIDE; PENICILLIN G BENETHAMINE; PENICILLIN G EPHEDRINE SALT; PENICILLIN G PROCAINE.
Oxacillin Specification
Oxacillin (CAS NO.66-79-5) is a narrow spectrum beta-lactam antibiotic of the penicillin class.
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