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Paromomycin sulfate salt

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Name

Paromomycin sulfate salt

EINECS 215-031-7
CAS No. 1263-89-4 Density N/A
PSA 430.30000 LogP -4.93220
Solubility water: 50 mg/mL Melting Point >200oC
Formula C23H45N5O14•H2O4S Boiling Point 939.8 °C at 760 mmHg
Molecular Weight 713.81 Flash Point 522.2 °C
Transport Information N/A Appearance powder
Safety 26-36/37-45-38-36 Risk Codes 23/24/25-61-36/37/38
Molecular Structure Molecular Structure of 1263-89-4 (PAROMOMYCIN SULFATE) Hazard Symbols IrritantXi
Synonyms

Aminosidine Sulphate;Paromomycin sulfate salt;Humatin (TN);Paromomycin sulfate (JAN/USP);Prestwick_1023;D-Streptamine,O-2-amino-2-deoxy-R-Dglucopyranosyl-( 1f4)-O-[O-2,6-diamino-2,- 6-dideoxy-a-L-idopyranosyl-(1f3)-a-Dribofuranosyl-( 1f5)]-2-deoxy-,sulfate (salt);Paromomycin sulfate;Gabbroral;Humatin;5-amino-6-[4,6-diamino-2-[(3S,4S,5R)-4-[3-amino-6-(aminomethyl)-4,5-dihydroxy-oxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-2-(hydroxymethyl)oxane-3,4-diol; sulfuric acid;(2R,3S,4R,5R,6S)-5-amino-6-[(1R,2S,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4R,5R)-4-[(2R,3R,4R,5R,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxy-oxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-2-(hydroxymethyl)oxane-3,4-diol; sulfuric acid;

 

Paromomycin sulfate salt Specification

This chemical is called Paromomycin sulphates, and it's also named as D-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-beta-D-ribofuranosyl-(1-5))-2-deoxy-, sulfate (salt). With the classification codes Anthelmintic; Anti-amebic; Drug / Therapeutic Agent; Mutation data, its product categories are Antibiotics A to; A ntibiotics by Application; Chemical Structure Class; Genetic Marker Selection Antibiotics; Interferes with Protein Synthesis Spectrum of Activity; Mechanism of Action. The CAS registry number of this chemical is 1263-89-4. Additionally, it should be stored at 0-6°C where the room is dry and ventilated. Keep the Paromomycin sulphates away from the oxidants.

Other characteristics of the Paromomycin sulphates can be summarised as followings: (1)ACD/LogP: -3.27; (2)# of Rule of 5 Violations: 3; (3)ACD/LogD (pH 5.5): -10.06; (4)ACD/LogD (pH 7.4): -8.33; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 19; (10)#H bond donors: 18; (11)#Freely Rotating Bonds: 22; (12)Polar Surface Area: 145.42 Å2; (13)Flash Point: 522.2 °C; (14)Enthalpy of Vaporization: 155.13 kJ/mol; (15)Boiling Point: 939.8 °C at 760 mmHg; (16)Vapour Pressure: 0 mmHg at 25°C.

Uses of this chemical: The Paromomycin sulphates is an oligosaccharide antibiotic produced by various streptomyces. It's aminoglycoside antibiotics. Generally, this chemical is used on the treatment of bacillary dysentery and other gastrointestinal infections. It can also cure amoebic dysentery. Moreover, you can find that it used on fire extinguishing agents, dry powder, foam, sand, carbon dioxide and water spray.

When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin. It may cause harm to the unborn child. You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1.InChI: InChI=1/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18?,19-,20-,21-,22-,23?;/m1./s1 
2.Smiles:O1[C@H](O[C@H]2[C@@H](O)[C@@H](O[C@H]3[C@@H](O[C@@H]4[C@H](N)[C@H]([C@@H]([C@H](O4)CO)O)O)[C@@H](N)C[C@H](N)[C@@H]3O)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]([C@@H]1CN)O.OS(=O)(O)=O

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 subcutaneous 1700mg/kg (1700mg/kg)   Chemotherapy Vol. 16, Pg. 105, 1968.
monkey LDLo intravenous 93mg/kg (93mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Antibiotics and Chemotherapy Vol. 9, Pg. 730, 1959.
mouse LD50 intracrebral 22300ug/kg (22.3mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Chemotherapy Vol. 16, Pg. 114, 1968.
mouse LD50 intramuscular 438mg/kg (438mg/kg)   Japanese Journal of Antibiotics. Vol. 36, Pg. 644, 1983.
mouse LD50 intraperitoneal 750mg/kg (750mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Chemotherapy Vol. 16, Pg. 114, 1968.
mouse LD50 intravenous 90mg/kg (90mg/kg)   Therapie. Vol. 16, Pg. 184, 1961.
mouse LD50 oral 23500mg/kg (23500mg/kg)   Japanese Journal of Antibiotics. Vol. 36, Pg. 644, 1983.
mouse LD50 subcutaneous 123mg/kg (123mg/kg)   Therapie. Vol. 16, Pg. 184, 1961.
rat LD50 intramuscular 1200mg/kg (1200mg/kg)   Drugs in Japan Vol. 6, Pg. 595, 1982.
rat LD50 intravenous 181mg/kg (181mg/kg)   Antibiotics and Chemotherapy Vol. 9, Pg. 730, 1959.
rat LD50 oral 21620mg/kg (21620mg/kg)   Drugs in Japan Vol. 6, Pg. 595, 1982.
rat LD50 subcutaneous 870mg/kg (870mg/kg) PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Chemotherapy Vol. 16, Pg. 114, 1968.

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