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Piperazine-1,4-diethylamine
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Name

Piperazine-1,4-diethylamine

 EINECS 229-428-8
CAS No. 6531-38-0 Density 1.006g/cm3
PSA 58.52000 LogP -0.20220
Solubility N/A Melting Point 40 °C
Formula C8H20N4 Boiling Point 302.2 °C at 760 mmHg
Molecular Weight 172.274 Flash Point 151.4 °C
Transport Information N/A Appearance N/A
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 6531-38-0 (Piperazine-1,4-diethylamine) Hazard Symbols N/A
Synonyms

Piperazine,1,4-bis(2-aminoethyl)- (7CI,8CI);1,4-Bis(2-aminoethyl)-1,4-diazacyclohexane;1,4-Bis(2-aminoethyl)piperazine;1,4-Piperazinediethylamine;N,N'-Bis(2-aminoethyl)piperazine;[2-[4-(2-Aminoethyl)piperazin-1-yl]ethyl]amine;

Article Data 19

Piperazine-1,4-diethylamine Synthetic route

5623-99-4

2‐[4‐(cyanomethyl)piperazin‐1‐yl]acetonitrile

6531-38-0

1,4-bis(2-aminoethyl)piperazine

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 4h; Reflux;87%
Stage #1: 2‐[4‐(cyanomethyl)piperazin‐1‐yl]acetonitrile With lithium aluminium tetrahydride In tetrahydrofuran for 3h; Heating / reflux;
Stage #2: With potassium hydroxide In tetrahydrofuran; water		80%
With ammonia; hydrogen; nickel In ethanol at 20℃;73%
20541-87-1

N,N'-bis(2-phthalimidoethyl)piperazine

6531-38-0

1,4-bis(2-aminoethyl)piperazine

Conditions
ConditionsYield
With potassium hydroxide; sodium hydroxide at 300 - 330℃;75%
With hydrogenchloride at 130℃; im Rohr;
With hydrazine hydrate
With hydrazine
151-56-4

ethyleneimine

140-31-8

aminoethylpiperazine

A

6531-38-0

1,4-bis(2-aminoethyl)piperazine

B

24028-46-4

1-<2-(2-aminoethyl)aminoethyl>piperazine

Conditions
ConditionsYield
With hydrogenchloride In water at 50℃;A 79.5 % Chromat.
B 20.5 % Chromat.
With hydrogenchloride In water at 25℃; Kinetics; Thermodynamic data; acid-catalyzed ring opening reactions at various temperature, Ea, ΔH are given;
With hydrogenchloride In water at 40℃;A 80.0 % Chromat.
B 20.0 % Chromat.
piperazine-N.N'-diacetic acid dinitrile

piperazine-N.N'-diacetic acid dinitrile

6531-38-0

1,4-bis(2-aminoethyl)piperazine

Conditions
ConditionsYield
With ethanol; sodium
131543-46-9

Glyoxal

112-24-3

triethylentetramine

6531-38-0

1,4-bis(2-aminoethyl)piperazine

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol at -10℃; for 2h;
With sodium tetrahydroborate
With sodium tetrahydroborate In ethanol at 0℃; for 2h;
84429-08-3

N,N'-Bis(2-phthalimidoethyl)ethylene diamine

6531-38-0

1,4-bis(2-aminoethyl)piperazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 61 percent / potassium carbonate / 0.17 h / 132 °C
2: 75 percent / aq.sodium hydroxide, potassium hydroxide / 300 - 330 °C
View Scheme
112-24-3

triethylentetramine

6531-38-0

1,4-bis(2-aminoethyl)piperazine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 65 percent / 195 °C
2: 61 percent / potassium carbonate / 0.17 h / 132 °C
3: 75 percent / aq.sodium hydroxide, potassium hydroxide / 300 - 330 °C
View Scheme
6531-38-0

1,4-bis(2-aminoethyl)piperazine

C15H11NO3

C38H38N6O4

Conditions
ConditionsYield
In ethanol at 80℃; for 8h;92%
6531-38-0

1,4-bis(2-aminoethyl)piperazine

nickel(II) perchlorate hexahydrate

(3-[4-(3-aminopropyl)-piperazin-1-yl]-propylamine)nickel(II) perchlorate

Conditions
ConditionsYield
In methanol refluxed for 2 h; ppt. filtered, washed with cold MeOH, dried; elem. anal.;90%
6531-38-0

1,4-bis(2-aminoethyl)piperazine

37942-07-7

3,5-di-tert-butyl-2-hydroxybenzaldehyde

N,N'-bis{2-[(2-ethylimino)methyl]-4,6-di-tert-butylphenol}piperazine

Conditions
ConditionsYield
In ethanol for 3h; Reflux;87%

Piperazine-1,4-diethylamine Specification

The Piperazine-1,4-diethylamine, with CAS registry number 6531-38-0, belongs to the following product categorie: Piperidine. It has the systematic name of 2,2'-piperazine-1,4-diyldiethanamine. And its IUPAC name is 2-[4-(2-aminoethyl)piperazin-1-yl]ethanamine. What's more, its EINECS is 229-428-8.

Physical properties about this chemical are: (1)ACD/LogP: -1.97; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -6.09; (4)ACD/LogD (pH 7.4): -5.95; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 4; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 6; (12)Polar Surface Area: 12.96 Å2; (13)Index of Refraction: 1.511; (14)Molar Refractivity: 51.3 cm3; (15)Molar Volume: 171 cm3; (16)Polarizability: 20.33×10-24cm3; (17)Surface Tension: 41 dyne/cm; (18)Enthalpy of Vaporization: 54.24 kJ/mol; (19)Vapour Pressure: 0.00101 mmHg at 25°C.

Preparation: this chemical can be prepared by piperazine-1,4-diyl-bis-acetonitrile. This reaction will need reagent H2, NH3. The temperature of this chemical is 20 ℃. The yield is about 73%.

Uses of Piperazine-1,4-diethylamine: it can be used to produce N,N'-(2,2'-piperazine-1,4-diyl-diethyl)-bis-phthalimide. This reaction will need reagent Condensation and solvent acetic acid.  The yield is about 80%.

You can still convert the following datas into molecular structure:
(1)SMILES: NCCN1CCN(CC1)CCN
(2)InChI: InChI=1/C8H20N4/c9-1-3-11-5-7-12(4-2-10)8-6-11/h1-10H2
(3)InChIKey: PAOXFRSJRCGJLV-UHFFFAOYAC
(4)Std. InChI: InChI=1S/C8H20N4/c9-1-3-11-5-7-12(4-2-10)8-6-11/h1-10H2
(5)Std. InChIKey: PAOXFRSJRCGJLV-UHFFFAOYSA-N

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