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Name	Pravastatin sodium	EINECS	1806241-263-5
CAS No.	81131-70-6	Density	N/A
PSA	124.29000	LogP	2.55290
Solubility	N/A	Melting Point	171.2-173 °C
Formula	C₂₃H₃₅NaO₇	Boiling Point	634.5 °C at 760 mmHg
Molecular Weight	446.516	Flash Point	213.2 °C
Transport Information	N/A	Appearance	white crystalline powder
Safety	16-26-36/37/39-45	Risk Codes	11-34
Molecular Structure		Hazard Symbols	F,C
Synonyms	Mevalotin;Pravachol;Pravachol (TN);Pravastatine [French];1-Naphthaleneheptanoic acid,1,2,6,7,8,8a-hexahydro-a,?,6-trihydroxy- 2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-,monosodium salt,(aR,?R,1S,2S,6S,8S,8aR)-;Pravastatina [Spanish];Pravastatinum [Latin];1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-beta,delta,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, (1S-(1alpha(betas,deltas),2alpha,6alpha,8beta(R*),8aalpha))-;sodium (3R,5R)-7-[(1S,2R,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxy-heptanoate;1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-beta,delta,6-trihydroxy-2-methyl-8-((2S)-2-methyl-1-oxobutoxy)-, (betaR,deltaR,1S,2S,6S,8S,8aR)-;Lipostat;SQ 31000;Paravastatin;	Article Data	18

Pravastatin sodium Chemical Properties

Molecular Structure of Pravastatin sodium (CAS NO.81131-70-6):

IUPAC Name: Sodium(3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
Molecular Weight: 446.50957 [g/mol]
Molecular Formula: C₂₃H₃₅NaO₇
H-Bond Donor: 3
H-Bond Acceptor: 7
Appearance: White Crystalline Powder
Melting Point: 171.2-173 °C
storage temp.: 2-8 °C
solubility: H₂O: 19 mg/mL
Flash Point: 213.2 °C
Enthalpy of Vaporization: 107.45 kJ/mol
Boiling Point: 634.5 °C at 760 mmHg
Vapour Pressure: 9.15E-19 mmHg at 25 °C
Classification Code: Antihyperlipidemic; Drug / Therapeutic Agent; Human Data
Product Categories: Active Pharmaceutical Ingredients; Antihyperlipoproteinemic; Various Metabolites and Impurities; Chiral Reagents; Intermediates & Fine Chemicals; Metabolites & Impurities; Pharmaceuticals; HMG-CoA reductase

Pravastatin sodium Uses

Pravastatin sodium (CAS NO.81131-70-6) can be used as a competitive inhibitor of HMG-CoA reductase, Bioactive metabolite of Mevastatin

Pravastatin sodium Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	16mg/kg/8W-I (16mg/kg)	LIVER: "JAUNDICE, CHOLESTATIC" LIVER: LIVER FUNCTION TESTS IMPAIRED SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	American Journal of Emergency Medicine. Vol. 17, Pg. 1388, 1999.
mouse	LD50	intravenous	2011mg/kg (2011mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 4949, 1987.
mouse	LD50	oral	8939mg/kg (8939mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BLOOD: CHANGES IN SPLEEN	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 4949, 1987.
mouse	LD50	subcutaneous	2975mg/kg (2975mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 4949, 1987.
rat	LD50	intravenous	440mg/kg (440mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 4949, 1987.
rat	LD50	oral	> 12gm/kg (12000mg/kg)		Yakkyoku. Pharmacy. Vol. 40, Pg. 2351, 1989.
rat	LD50	subcutaneous	3172mg/kg (3172mg/kg)	BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 4949, 1987.
rat	LDLo	intraperitoneal	400mg/kg (400mg/kg)		Biochemistry and Molecular Biology International. Vol. 47, Pg. 519, 1999.
women	TDLo	oral	16800ug/kg (16.8mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Lancet. Vol. 340, Pg. 910, 1992.
women	TDLo	oral	30mg/kg/21W-I (30mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)" SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	New England Journal of Medicine. Vol. 327, Pg. 649, 1992.

Pravastatin sodium Safety Profile

Moderately toxic by intravenous and intraperitoneal. Low toxicity by ingestion. Human systemic effects. When heated to decomposition it emits acrid smoke and irritating vapors.
Safety Information of Pravastatin sodium (CAS NO.81131-70-6):
Hazard Codes: F, Corrosive C
Risk Statements: 11-34
R11:Highly flammable.
R34:Causes burns.
Safety Statements: 16-26-36/37/39-45
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: 3077
WGK Germany: 2
RTECS: QJ7185000
HazardClass: 9
PackingGroup: III

Pravastatin sodium Specification

Pravastatin sodium (CAS NO.81131-70-6), its Synonyms are 3-beta-Hydroxycompactin sodium salt ; Aplactin ; Bristacol ; Pravachol ; Pravacol ; Pravaselect ; Pravasin ; Pravasine ; Pravastatin Natrium Mayrho Fer ; Sanaprav ; Selektine ; Selipran ; Sodium (+)-(betaR,deltaR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-hexahydro-beta,delta,6,8-tetrahydroxy-2-methyl-1-naphthaleneheptanoate, 8-((2S)-2-methylbutyrate) .

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