2,4-DI-TERT-BUTYLANILINE

Base Information

• Chemical Name: 2,4-DI-TERT-BUTYLANILINE
• CAS No.: 2909-84-4
• Molecular Formula: C14H23N
• Molecular Weight: 205.343
• Hs Code.: 2921420090
• Mol file: 2909-84-4.mol

Synonyms:2,4-di-tert-butylaniline;Aniline,2,4-di-tert-butyl;2,4-Di-tert-butylanilin;2,4-di-t-butylaniline;

Chemical Property of 2,4-DI-TERT-BUTYLANILINE

Chemical Property:

• Melting Point: 18.5-19 °C
• Boiling Point: 140-141 °C(Press: 13 Torr)
• PKA: 4.11±0.10(Predicted)
• PSA: 26.02000
• Density: 0.9176 g/cm3(Temp: 25 °C)
• LogP: 4.44500
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98% ^*data from raw suppliers

2,4-Di-tert-butylaniline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DI-TERT-BUTYLANILINE

There total 12 articles about 2,4-DI-TERT-BUTYLANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,4-di-tert-butyl-1-nitrobenzene (93720-37-7) → 2,4-bis(1,1-dimethylethyl)benzenamine (2909-84-4)

Guidance literature:

With palladium on activated carbon; hydrazine hydrate; In ethanol; for 16h; Inert atmosphere; Reflux;

DOI:10.1002/anie.202007595

Reference yield: 55.0%

1-chloro-2-nitro-3,5-di-tert-butylbenzene (80438-68-2) → 2,4-bis(1,1-dimethylethyl)benzenamine (2909-84-4) + 2-chloro-4,6-di-tert-butylaniline (80438-53-5)

Guidance literature:

With hydrogen; nickel; In ethanol; for 7h; under 760 Torr;

Reference yield: 30.0%

1,3-di-tert-butylbenzene (1014-60-4) → 2,4-bis(1,1-dimethylethyl)benzenamine (2909-84-4)

Guidance literature:

1,3-di-tert-butylbenzene; With pyridine; trifluorormethanesulfonic acid; tetrabutylammonium tetrafluoroborate; In acetonitrile; at 22 ℃; Electrochemical reaction;

With piperidine; In acetonitrile; at 80 ℃; for 12h;

DOI:10.1002/ejoc.201600048

upstream raw materials:

2,4-di-tert-butyl-1-nitrobenzene

3,5-di(tert-butyl)-2-nitro-1-bromobenzene

1-chloro-2-nitro-3,5-di-tert-butylbenzene

3,5-di-tert-butyl-2-nitroaniline

Downstream raw materials:

2-bromo-4,6-di-tert-butylacetanilide

2-iodo-4,6-di-tert-butylacetanilide

Refernces

• 1、 Wang, Tao,Hoffmann, Marvin,Dreuw, Andreas,Hasagi?, Edina,Hu, Chao,Stein, Philipp M.,Witzel, Sina,Shi, Hongwei,Yang, Yangyang,Rudolph, Matthias,Stuck, Fabian,Rominger, Frank,Kerscher, Marion,Comba, Peter,Hashmi, A. Stephen K.. "A Metal-Free Direct Arene C?H Amination". supporting information. p. 2783 - 2795. Retrieved 2021/04/05.
• 2、 Clayden, Jonathan,Costil, Romain,Duarte, Fernanda,Sterling, Alistair J.. "Atropisomerism in Diarylamines: Structural Requirements and Mechanisms of Conformational Interconversion". supporting information. p. 18670 - 18678. Retrieved 2020/08/25.