(2-hydroxy-4,6-dimethylphenyl)(phenyl)methanone

Base Information

• Chemical Name: (2-hydroxy-4,6-dimethylphenyl)(phenyl)methanone
• CAS No.: 2929-45-5
• Molecular Formula: C15H14O2
• Molecular Weight: 226.275
• Mol file: 2929-45-5.mol

Synonyms:2-Hydroxy-4,6-dimethylbenzophenon;1-benzoyl-2-hydroxy-4,6-dimethylbenzene;1-benzoyl-2-chloroindole-3-carboxaldehyde;1-Benzoyl-2-chlorindol-3-carbaldehyd;1-benzoyl-2-chloro-indole-3-carbaldehyde;2-hydroxy-4,6-dimethyl-benzophenone;

Chemical Property of (2-hydroxy-4,6-dimethylphenyl)(phenyl)methanone

Chemical Property:

• Vapor Pressure: 5.25E-05mmHg at 25°C
• Melting Point: 143–143.5°C
• Boiling Point: 337.7oC at 760 mmHg
• Flash Point: 143.7oC
• PSA: 37.30000
• Density: 1.139g/cm3
• LogP: 3.24000

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-hydroxy-4,6-dimethylphenyl)(phenyl)methanone

There total 15 articles about (2-hydroxy-4,6-dimethylphenyl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

C10H13NO2 + diphenyl acetylene (501-65-5) → (2-hydroxy-4,6-dimethylphenyl)(phenyl)methanone (2929-45-5)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate; In methanol; at 50 ℃; for 24h; Sealed tube;

DOI:10.1039/c6cc05769a

Reference yield: 51.0%

carbon monoxide (201230-82-2) + 2-iodo-3,5-dimethyl-phenol (24242-79-3) + phenylboronic acid (98-80-6) → (2-hydroxy-4,6-dimethylphenyl)(phenyl)methanone (2929-45-5)

Guidance literature:

With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride; potassium carbonate; In chlorobenzene; at 80 ℃; for 24h; under 760.051 Torr; Inert atmosphere;

DOI:10.1021/ol802202j

Reference yield: 45.0%

benzoyl chloride (98-88-4) + 3,5-Dimethylphenol (108-68-9,50356-23-5) → (2-hydroxy-4,6-dimethylphenyl)(phenyl)methanone (2929-45-5)

Guidance literature:

With aluminium trichloride; In nitromethane; at 25 ℃; 1.) 3 h, 2.) reflux, 1 h;

upstream raw materials:

(3,5-Dimethylphenyl)benzoat

benzoic acid

3,5-Dimethylphenol

benzoic acid-(2-bromo-4,5-dimethyl-phenyl ester)

Downstream raw materials:

1-benzoyl-2-methoxy-4,6-dimethylbenzene

(3,5-Dimethylphenyl)benzoat

(4-Hydroxy-2,6-dimethylphenyl)phenylketon

Refernces

• 1、 Xie, Ying. "Acylation of Csp2-H bond with acyl sources derived from alkynes: Rh-Cu bimetallic catalyzed CC bond cleavage". supporting information. p. 12372 - 12375. Retrieved 2016/10/22.
• 2、 Michael O'Keefe,Simmons, Nicholas,Martin, Stephen F.. "Carbonylative cross-coupling of ortho-disubstituted aryl iodides. Convenient synthesis of sterically hindered aryl ketones". supporting information; experimental part. p. 5301 - 5304. Retrieved 2009/06/18.