24242-79-3Relevant articles and documents
NLRP3 INFLAMMASOME INHIBITORS
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Paragraph 0703-0704, (2020/12/04)
The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I): wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammaso
Selectivity enhancement of aromatic halogenation reactions at the micellar interface: Effect of highly ionic media
Samant, Bhupesh S.,Bhagwat, Sunil S.
scheme or table, p. 1039 - 1044 (2012/10/18)
Halogenation (iodination and bromination) of various aromatic compounds has been studied in micellar media in order to observe the effect on regioselectivity and conversion of the reaction. The addition of surfactant causes a change in the chemical shifts of the aromatic proton resonance of phenol which proves the orientation of the aromatic compound on the micellar surface. However, increase in ionic strength of the reaction media affects the selectivity of reaction by disturbing this spatial orientation of the aromatic compound in the micelle. Selectivity towards particular isomers is dependent on the concentration of the surfactant. In bromination of chlorobenzene (deactivated aromatic compound) enhancement in selectivity and conversion towards the para isomer has been observed.
Iodination of aromatic compounds using potassium iodide and hydrogen peroxide
Reddy, K. Suresh Kumar,Narender,Rohitha,Kulkarni
experimental part, p. 3894 - 3902 (2009/04/04)
A simple, efficient, regioselective, and ecofriendly method for oxyiodination of aromatic compounds is presented. In this method, the electrophilic substitutions of iodine generated in situ from KI as an iodine source and hydrogen peroxide as an oxygen source have been employed without any catalyst/mineral acid for the first time. Copyright Taylor & Francis Group, LLC.