1082070-26-5

Basic information

• Product Name: 1-(2'-methoxy-4',6'-dimethylphenyl)-3-phenylprop-2-yn-1-one
• Synonyms: 1-(2'-methoxy-4',6'-dimethylphenyl)-3-phenylprop-2-yn-1-one
• CAS NO: 1082070-26-5
• Molecular Weight: 264.324
• Mol File: 1082070-26-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(2'-methoxy-4',6'-dimethylphenyl)-3-phenylprop-2-yn-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2'-methoxy-4',6'-dimethylphenyl)-3-phenylprop-2-yn-1-one(1082070-26-5)
• EPA Substance Registry System: 1-(2'-methoxy-4',6'-dimethylphenyl)-3-phenylprop-2-yn-1-one(1082070-26-5)

Safety Data

• Hazardous Substances Data: 1082070-26-5(Hazardous Substances Data)

Upstream product

• 24242-79-3 2-iodo-3,5-dimethyl-phenol 
• 201230-82-2 carbon monoxide 
• 65434-71-1 2-iodo-1-methoxy-3,5-dimethylbenzene 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 536-74-3 phenylacetylene 

Relevant articles and documents

Facile access to sterically hindered aryl ketones via carbonylative cross-coupling: Application to the total synthesis of luteolin

A general and mild protocol for achieving the carbonylative cross-coupling of sterically hindered, ortho-disubstituted aryl ketones is reported. The commercially available PEPPSI-IPr catalyst is shown to efficiently promote the carbonylative cross-coupling of hindered ortho-disubstituted aryl iodides to give diaryl ketones; traditional phosphine catalysts are less effective. Carbonylative Suzuki-Miyaura cross-couplings provide a diverse array of biaryl ketones in good to excellent yields. The same catalyst is also shown to catalyze a carbonylative Negishi cross-coupling reaction, utilizing a variety of alkynyl-zinc reagents to give the corresponding alkynyl aryl ketones. Application of this new methodology to the synthesis of the natural product luteolin is reported.