Ethanol, 2-[(4-methoxyphenyl)amino]-

Base Information

• Chemical Name: Ethanol, 2-[(4-methoxyphenyl)amino]-
• CAS No.: 2933-77-9
• Molecular Formula: C9H13NO2
• Molecular Weight: 167.208
• DSSTox Substance ID: DTXSID10485586
• Nikkaji Number: J2.674.453I
• Wikidata: Q82324885
• Mol file: 2933-77-9.mol

Synonyms:Ethanol, 2-[(4-methoxyphenyl)amino]-;2933-77-9;2-(4-Methoxyanilino)ethanol;SCHEMBL4061071;N-(2-hydroxyethyl)-p-anisidine;DTXSID10485586;AWTLUMCKTGWXNY-UHFFFAOYSA-N;2-(4-methoxy-phenylamino)-ethanol;AKOS000258496;2-[(4-METHOXYPHENYL)AMINO]ETHANOL

Chemical Property of Ethanol, 2-[(4-methoxyphenyl)amino]-

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 167.094628657
• Heavy Atom Count: 12
• Complexity: 111

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)NCCO

Technology Process of Ethanol, 2-[(4-methoxyphenyl)amino]-

There total 15 articles about Ethanol, 2-[(4-methoxyphenyl)amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

para-iodoanisole (696-62-8) + ethanolamine (141-43-5) → N-(2-hydroxyethyl)-4-methoxyaniline (2933-77-9)

Guidance literature:

With aluminum oxide; copper; potassium hydroxide; for 0.5h;

DOI:10.1055/s-0035-1560173

Reference yield: 95.0%

1-bromo-4-methoxy-benzene (104-92-7) + ethanolamine (141-43-5) → N-(2-hydroxyethyl)-4-methoxyaniline (2933-77-9)

Guidance literature:

With potassium phosphate; copper(l) iodide; CVT-2537; In dimethyl sulfoxide; at 90 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol301135c

Reference yield: 88.0%

[1,3]-dioxolan-2-one (96-49-1) + 4-methoxy-aniline (104-94-9) → N-(2-hydroxyethyl)-4-methoxyaniline (2933-77-9) + 2-[(2-hydroxyethyl)-(4-methoxyphenyl)amino]ethanol (19721-54-1)

Guidance literature:

With Na-Y zeolite; In Triethylene glycol dimethyl ether; for 1h; Heating;

DOI:10.1055/s-2006-939697

upstream raw materials:

oxirane

4-methoxy-aniline

2-chloro-ethanol

N-(2-hydroxyethyl)-2-(4-methoxyphenoxy)acetamide

Downstream raw materials:

3-(4-methoxy-phenyl)-oxazolidine

1,4-bis(4-methoxyphenyl)piperazine

(R)-N-(p-methoxyphenyl)-3-phenylmorpholin-2-one

Refernces

• 1、 Nicewicz, David A.,Pistritto, Vincent A.,Schutzbach-Horton, Megan E.. "Nucleophilic aromatic substitution of unactivated fluoroarenes enabled by organic photoredox catalysis". supporting information. p. 17187 - 17194. Retrieved 2020/11/02.
• 2、 Yi, Zhou,Huang, Manna,Wan, Yiqian,Zhu, Xinhai. "An Effective Heterogeneous Copper Catalyst System for C-N Coupling and Its Application in the Preparation of 2-Methyl-4-methoxydiphenylamine (MMDPA)". . p. 3911 - 3920. Retrieved 2018/09/29.