2,2'-[(4-Methoxyphenyl)imino]diethanol

Base Information

• Chemical Name: 2,2'-[(4-Methoxyphenyl)imino]diethanol
• CAS No.: 19721-54-1
• Molecular Formula: C11H17NO3
• Molecular Weight: 211.261
• NSC Number: 103355
• DSSTox Substance ID: DTXSID20295613
• Nikkaji Number: J141.513A
• Wikidata: Q82035635
• Mol file: 19721-54-1.mol

Synonyms:19721-54-1;2,2'-[(4-methoxyphenyl)imino]diethanol;NSC103355;NCIOpen2_007099;SCHEMBL107407;DTXSID20295613;ADAL1072106;NSC-103355;2-[(2-hydroxyethyl)(4-methoxyphenyl)amino]ethan-1-ol

Chemical Property of 2,2'-[(4-Methoxyphenyl)imino]diethanol

Chemical Property:

• Boiling Point: 402°Cat760mmHg
• Flash Point: 196.9°C
• Density: 1.177g/cm³
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 211.12084340
• Heavy Atom Count: 15
• Complexity: 152

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)N(CCO)CCO

Technology Process of 2,2'-[(4-Methoxyphenyl)imino]diethanol

There total 11 articles about 2,2'-[(4-Methoxyphenyl)imino]diethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diethyl 2,2’-((4-methoxyphenyl)azanediyl)diacetate (98269-30-8) → 2-[(2-hydroxyethyl)-(4-methoxyphenyl)amino]ethanol (19721-54-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 24h; Reflux;

Reference yield: 88.0%

[1,3]-dioxolan-2-one (96-49-1) + 4-methoxy-aniline (104-94-9) → N-(2-hydroxyethyl)-4-methoxyaniline (2933-77-9) + 2-[(2-hydroxyethyl)-(4-methoxyphenyl)amino]ethanol (19721-54-1)

Guidance literature:

With Na-Y zeolite; In Triethylene glycol dimethyl ether; for 1h; Heating;

DOI:10.1055/s-2006-939697

Reference yield: 85.0%

4-methoxy-aniline (104-94-9) + 2-chloro-ethanol (107-07-3) → 2-[(2-hydroxyethyl)-(4-methoxyphenyl)amino]ethanol (19721-54-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; Reflux;

DOI:10.1021/acs.jmedchem.7b00738

upstream raw materials:

oxirane

4-methoxy-aniline

2-chloro-ethanol

N,N-bis(2-chloroethyl)-4-methoxybenzenamine

Downstream raw materials:

N,N-bis(2-chloroethyl)-4-methoxybenzenamine

N,N-bis(2-bromoethyl)-4-methoxyaniline

1-N-(4'-methoxyphenyl)-1-aza-4,7,10,13-tetraoxacyclopentadecane

N,N-bis-(2-benzoyloxy-ethyl)-p-anisidine

Refernces

• 1、 Neelarapu, Raghupathi,Maignan, Jordany R.,Lichorowic, Cynthia L.,Monastyrskyi, Andrii,Mutka, Tina S.,LaCrue, Alexis N.,Blake, Lynn D.,Casandra, Debora,Mashkouri, Sherwin,Burrows, Jeremy N.,Willis, Paul A.,Kyle, Dennis E.,Manetsch, Roman. "Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)-Quinolones with Potent Antimalarial Activity: Structure-Activity and Structure-Property Relationship Studies". . p. 1450 - 1473. Retrieved 2018/03/05.
• 2、 -. "FLUORESCENT PROBES FOR DETECTION OF COPPER". Paragraph 0204; 0236; 0239-0240. . Retrieved 2014/03/24.