2933-77-9

Basic information

• Product Name: Ethanol, 2-[(4-methoxyphenyl)amino]-
• CAS NO: 2933-77-9
• Molecular Formula: C9H13NO2
• Molecular Weight: 167.208
• Mol File: 2933-77-9.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: Ethanol, 2-[(4-methoxyphenyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2-[(4-methoxyphenyl)amino]-(2933-77-9)
• EPA Substance Registry System: Ethanol, 2-[(4-methoxyphenyl)amino]-(2933-77-9)

Safety Data

• Hazardous Substances Data: 2933-77-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 50-00-0 formaldehyd 
• 104-94-9 4-methoxy-aniline 
• 107-21-1 ethylene glycol 
• 459-60-9 1-fluoro-4-methoxybenzene 
• 141-43-5 ethanolamine 
• 627-11-2 2-Chloroethyl chloroformate 
• 5198-48-1 3-(4-methoxy-phenyl)-oxazolidin-2-one 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 1877-75-4 2-(4-methoxyphenoxy)acetic acid 
• 696-62-8 para-iodoanisole 
• 96-49-1 [1,3]-dioxolan-2-one 
• 51816-48-9 N-(2-hydroxyethyl)-2-(4-methoxyphenoxy)acetamide 
• 107-07-3 2-chloro-ethanol 

Downstream Products

• 80077-21-0 2-Chloro-3-(4-methoxy-phenyl)-[1,3,2]oxazaphospholidine 
• 1355025-43-2 (R)-N-(p-methoxyphenyl)-3-phenylmorpholin-2-one 
• 53332-62-0 2-((4-methoxyphenyl)methylamino)ethanol 
• 1251855-58-9 C₁₄H₁₉NO₄ 

Relevant articles and documents

Green synthesis of N-(2-hydroxyethyl)anilines by the selective alkylation reaction in H2O

Based on our previous work, a safer and more sustainable protocol for the synthesis of N-(2-Hydroxyethyl)anilines has been developed. The synthesis included the selective alkylation reaction of aniline with 2-chloroethanol in H2O, eliminating the need for any catalysts and solvents during synthesis. Comparing with our previous work, the salient features of this methodology are eco-friendliness, economic benefit, and the ease of obtaining target compounds. The selective alkylation reaction in H2O is amenable to scale-up for the synthesis of N-(2-Hydroxyethyl)anilines.

N-arylation method in aqueous phase system with substituted quinoline or isoquinoyl hydrazide pyridine-N-oxide as ligand

The invention relates to an N-arylation method in an aqueous phase system with substituted quinoline or isoquinoyl hydrazide pyridine-N-oxide as a ligand. The N-arylation method in the aqueous phase system with the substituted quinoline or isoquinoyl hydrazide pyridine-N-oxide as the ligand comprises the following steps of: adding a catalyst, the ligand, a raw material, alkali, a phase transferring catalyst and a solvent into a reactor, heating and stirring, after the reaction is ended, separating and purifying a reaction solution to obtain an N-arylation product, wherein the raw material is aryl halide and a nitrogen-containing nucleophilic reagent, the solvent is a mixed solution of water and ethanol, and the catalyst is metal copper, or a copper oxide, or monovalent copper salt, or bivalent copper salt. The N-arylation method in the aqueous phase system with substituted quinoline or isoquinoyl hydrazide pyridine-N-oxide as the ligand has the characteristics of simplicity in operation, wide substrate application range, simplicity and easiness in separating products, high yield, economical process, environmental protection and the like.

Room-Temperature CuI-Catalyzed Amination of Aryl Iodides and Aryl Bromides

A general and effective CuI/N′,N′-diaryl-1H-pyrrole-2-carbohydrazide catalyst system was developed for the amination of aryl iodides and bromides at room temperature with good chemoselectivity between -OH and -NH2 groups. Only 5 mol % of CuI and ligands was needed in this protocol to effect the amination of various aryl bromides and aryl iodides with a wide range of aliphatic and aryl amines (1.3 equiv).