2,3-DIMETHYL-6-NITROQUINOXALINE

Base Information

• Chemical Name: 2,3-DIMETHYL-6-NITROQUINOXALINE
• CAS No.: 2942-03-2
• Molecular Formula: C10H9N3O2
• Molecular Weight: 203.19700
• Hs Code.: 2933990090
• Mol file: 2942-03-2.mol

Synonyms:CCG-4;2,3-dimethyl-6-nitro-quinoxaline;6-Nitro-2,3-dimethyl-chinoxalin;2,3-Dimethyl-6-nitro-chinoxalin;

Chemical Property of 2,3-DIMETHYL-6-NITROQUINOXALINE

Chemical Property:

• Melting Point: 130-131oC
• PSA: 71.60000
• LogP: 2.67800

Purity/Quality:

98.5% ^*data from raw suppliers

2,3-Dimethyl-6-nitroquinoxaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,3-dimethyl-6-nitroquinoxaline is a useful reactant for the synthesis of organic products.

Technology Process of 2,3-DIMETHYL-6-NITROQUINOXALINE

There total 4 articles about 2,3-DIMETHYL-6-NITROQUINOXALINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

dimethylglyoxal (431-03-8) + 4-Nitrophenylene-1,2-diamine (99-56-9) → 2,3-dimethyl-6-nitroquinoxaline (2942-03-2)

Guidance literature:

With zirconium(IV) chloride; In methanol; at 20 ℃; for 0.0833333h;

DOI:10.1007/s11243-009-9294-9

Reference yield: 80.0%

3-hydroxy-2-butanon (513-86-0,52217-02-4,51555-24-9) + 4-Nitrophenylene-1,2-diamine (99-56-9) → 2,3-dimethyl-6-nitroquinoxaline (2942-03-2)

Guidance literature:

With hexaammonium heptamolybdate tetrahydrate; at 90 ℃; for 0.25h; Catalytic behavior; Microwave irradiation;

DOI:10.1016/j.crci.2012.06.007

Reference yield: 35.0%

4-Nitrophenylene-1,2-diamine (99-56-9) + but-3-yn-2-ol (2028-63-9) → 2,3-dimethyl-6-nitroquinoxaline (2942-03-2)

Guidance literature:

With mercury(II) diacetate; In tetrahydrofuran; at 60 ℃; for 14h;

DOI:10.1055/s-1985-31194

upstream raw materials:

4-Nitrophenylene-1,2-diamine

but-3-yn-2-ol

dimethylglyoxal

3-hydroxy-2-butanon

Downstream raw materials:

2,3-dimethyl-6-quinoxalinamine

2-[(2,3-dimethylquinoxalin-6-ylamino)methylene]malonic acid diethyl ester

6-Acetylamino-2,3-dimethyl-chinoxalin

N-(2,3-dimethylquinoxalin-6-yl)-1-(4-benzyl-piperidine)-carboxamide

Refernces

• 1、 Khongkow, Pasarat,Lomlim, Luelak,Nualnoi, Teerapat,Saetang, Jirakrit,Suwanhom, Paptawan,Tipmanee, Varomyalin. "Synthesis, biological evaluation, and in silico studies of new acetylcholinesterase inhibitors based on quinoxaline scaffold". . . Retrieved 2021/08/20.
• 2、 Moghaddam, Sevil Vaghefi,Valizadeh, Hassan. "Ionic liquid functionalized cellulose as an efficient heterogeneous catalyst for the facile and green synthesis of benzoxazine, pyrazine and quinoxaline derivatives in aqueous media". . p. 1517 - 1524. Retrieved 2016/07/06.