2,3-Dimethyl-6-quinoxalinamine

Base Information

• Chemical Name: 2,3-Dimethyl-6-quinoxalinamine
• CAS No.: 7576-88-7
• Molecular Formula: C10H11N3
• Molecular Weight: 173.217
• Hs Code.: 2933990090
• European Community (EC) Number: 804-331-9
• DSSTox Substance ID: DTXSID30226655
• Nikkaji Number: J632.191G
• Wikidata: Q83106138
• ChEMBL ID: CHEMBL4548867
• Mol file: 7576-88-7.mol

Synonyms:2,3-dimethylquinoxalin-6-amine;2,3-Dimethyl-6-quinoxalinamine;7576-88-7;6-Amino-2,3-dimethylquinoxaline;6-Quinoxalinamine, 2,3-dimethyl-;BRN 0126666;CCRIS 8302;MFCD01759944;5-25-11-00200 (Beilstein Handbook Reference);2,3-Dimethyl-quinoxalin-6-ylamine;Oprea1_733303;Oprea1_734848;SCHEMBL1770021;CHEMBL4548867;DTXSID30226655;STK803303;AKOS000104776;6-Amino-2,3-dimethylquinoxaline, 95%;LS-142953;BB 0217047;CS-0455414;FT-0676651;EN300-748900;5R-0644;J-507042;Z1201621367;4-(BENZO[B]THIOPHENE-3-SULFONYL)-PIPERAZINEHYDROCHLORIDE;JD6

Chemical Property of 2,3-Dimethyl-6-quinoxalinamine

Chemical Property:

• Vapor Pressure: 0.000111mmHg at 25°C
• Melting Point: 191-193oC
• Refractive Index: 1.6250 (estimate)
• Boiling Point: 336.6°Cat760mmHg
• PKA: 3.05±0.48(Predicted)
• Flash Point: 183.9°C
• PSA: 51.80000
• Density: 1.195g/cm³
• LogP: 2.41000
• Storage Temp.: 2-8°C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 173.095297364
• Heavy Atom Count: 13
• Complexity: 183

Purity/Quality:

98%min ^*data from raw suppliers

2,3-Dimethylquinoxalin-6-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N=C2C=C(C=CC2=N1)N)C

Technology Process of 2,3-Dimethyl-6-quinoxalinamine

There total 6 articles about 2,3-Dimethyl-6-quinoxalinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,3-dimethyl-6-nitroquinoxaline (2942-03-2) → 2,3-dimethyl-6-quinoxalinamine (7576-88-7)

Guidance literature:

With 5% Pd(II)/C(eggshell); hydrogen; In ethanol; at 20 ℃;

DOI:10.1016/j.bmcl.2011.02.055

Reference yield: 8.0%

methyllithium (917-54-4) + 2-methyl-6-amino-quinoxaline (4188-17-4) → 2,3-dimethyl-6-quinoxalinamine (7576-88-7)

Guidance literature:

methyllithium; 2-methyl-6-amino-quinoxaline; In tetrahydrofuran; at -78 ℃; for 2h;

With manganese(IV) oxide; In chloroform; for 4h; Further stages.; Heating;

DOI:10.3987/com-06-s(k)19

Reference yield:

1,2,4-triaminobenzene hydrochloride + dimethylglyoxal (431-03-8) → 2,3-dimethyl-6-quinoxalinamine (7576-88-7)

Guidance literature:

In sodium carbonate;

upstream raw materials:

benzene-1,2,4-triamine dihydrochloride

dimethylglyoxal

2,3-dimethyl-6-nitroquinoxaline

methyllithium

Downstream raw materials:

N-benzenesulphonyl-N,2,3-trimethyl-6-quinoxalinamine

2-amino-3,7,8-trimethylimidazo[4,5-f]quinoxaline

N,2,3-trimethyl-5-nitro-6-quinoxalinamine

N,2,3-trimethyl-6-quinoxalinamine

Refernces

• 1、 Rajule, Rajkumar,Bryant, Vashti C.,Lopez, Hernando,Luo, Xu,Natarajan, Amarnath. "Perturbing pro-survival proteins using quinoxaline derivatives: A structure-activity relationship study". scheme or table. p. 2227 - 2234. Retrieved 2012/06/01.
• 2、 Hui, Xu,Schmidt, Fanny,Fakhfakh, Mohammed Akram,Franck, Xavier,Figadère, Bruno. "Novel highly regioselective syntheses of unsymmetrical 2,3-disubstituted quinoxalines". . p. 353 - 361. Retrieved 2008/03/12.