2-(Methylsulphonyl)nitrobenzene, 1-(Methylsulphonyl)-2-nitrobenzene

Base Information

• Chemical Name: 2-(Methylsulphonyl)nitrobenzene, 1-(Methylsulphonyl)-2-nitrobenzene
• CAS No.: 2976-34-3
• Molecular Formula: C7H7NO4S
• Molecular Weight: 201.203
• Hs Code.: 2904909090
• Mol file: 2976-34-3.mol

Synonyms:METHYL 2-NITROPHENYL SULFONE;METHYL 2-NITROPHENYL SULPHONE;

Chemical Property of 2-(Methylsulphonyl)nitrobenzene, 1-(Methylsulphonyl)-2-nitrobenzene

Chemical Property:

• Melting Point: 106 °C
• Boiling Point: 403.2±37.0 °C(Predicted)
• PSA: 88.34000
• Density: 1.406±0.06 g/cm3(Predicted)
• LogP: 2.60230

Purity/Quality:

95% ^*data from raw suppliers

Methyl2-nitrophenylsulphone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Methylsulphonyl)nitrobenzene, 1-(Methylsulphonyl)-2-nitrobenzene

There total 26 articles about 2-(Methylsulphonyl)nitrobenzene, 1-(Methylsulphonyl)-2-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

o-nitroiodobenzene (609-73-4) + sodium methansulfinate (20277-69-4) → 1-(methylsulfonyl)-2-nitrobenzene (2976-34-3)

Guidance literature:

With copper(l) iodide; In dimethyl sulfoxide; for 24h; Heating;

DOI:10.1055/s-2007-990778

Reference yield: 91.4%

bromoacetic acid (79-08-3) + 2-nitrobenzenesulfinic acid (13165-79-2) → 1-(methylsulfonyl)-2-nitrobenzene (2976-34-3)

Guidance literature:

With sodium hydroxide; In water; 1.) 30 min 2.) reflux, 24 h;

DOI:10.1002/hlca.19800630610

Reference yield: 91.0%

2-nitrophenyl bromide (577-19-5) + sodium methansulfinate (20277-69-4) → 1-(methylsulfonyl)-2-nitrobenzene (2976-34-3)

Guidance literature:

With copper(l) iodide; In dimethyl sulfoxide; for 32h; Heating;

DOI:10.1055/s-2007-990778

upstream raw materials:

methyl 2-nitrophenyl sulfide

<(2-Nitro-phenyl)sulfonyl>essigsaeure

2-nitrobenzenesulfinic acid

methyl iodide

Downstream raw materials:

α--phenylessigsaeure

N-(2-(methylsulfonyl)phenyl)acetamide

o-mercaptophenyl methyl sulfone

o-methylsulphonylphenyl methyl sulphide

Refernces

• 1、 Yang, Yu,Bao, Yajie,Guan, Qianqian,Sun, Qi,Zha, Zhenggen,Wang, Zhiyong. "Copper-catalyzed: S -methylation of sulfonyl hydrazides with TBHP for the synthesis of methyl sulfones in water". . p. 112 - 116. Retrieved 2017/08/15.
• 2、 Yamaguchi, Tetsufumi,Matsumoto, Kazuhiro,Saito, Bunnai,Katsuki, Tsutomu. "Asymmetric oxidation catalysis by a chiral Al(salalen) complex: Highly enantioselective oxidation of sulfides with aqueous hydrogen peroxide". . p. 4729 - 4731. Retrieved 2008/02/09.