6H-Purin-6-one, 1,9-dihydro-9-methyl- (9CI)

Base Information

• Chemical Name: 6H-Purin-6-one, 1,9-dihydro-9-methyl- (9CI)
• CAS No.: 875-31-0
• Molecular Formula: C6H6 N4 O
• Molecular Weight: 150.14
• Hs Code.: 2933990090
• Mol file: 875-31-0.mol

Synonyms:Hypoxanthine,9-methyl- (7CI,8CI); 9-Methylhypoxanthine; NSC 4918

Chemical Property of 6H-Purin-6-one, 1,9-dihydro-9-methyl- (9CI)

Chemical Property:

• Vapor Pressure: 3.41E-08mmHg at 25°C
• Refractive Index: 1.6700 (estimate)
• Boiling Point: 447.3°C at 760 mmHg
• Flash Point: 224.3°C
• PSA: 63.57000
• Density: 1.6g/cm³
• LogP: -0.34340

Purity/Quality:

98%,99%, ^*data from raw suppliers

9-Methyl-9H-purin-6-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6H-Purin-6-one, 1,9-dihydro-9-methyl- (9CI)

There total 22 articles about 6H-Purin-6-one, 1,9-dihydro-9-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3-methyladenine (700-00-5) → 9-methylhypoxanthine (875-31-0)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at 90 ℃; for 0.833333h;

DOI:10.1248/cpb.40.612

Reference yield: 77.0%

ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate (31037-02-2) + formamide (77287-34-4,77287-35-5,60100-09-6) → 9-methylhypoxanthine (875-31-0)

Guidance literature:

at 180 ℃; for 4h;

DOI:10.1002/jhet.1891

Reference yield: 53.0%

9-methyl-6-(ω-p-methylbenzoylbutylthio)purine (276873-36-0) → 9-methylhypoxanthine (875-31-0)

Guidance literature:

With hydrogenchloride; for 1h; Heating;

DOI:10.1007/BF02323383

upstream raw materials:

formic acid

5-amino-1-methyl-1H-imidazole-4-carboxamide

acetic anhydride

5-amino-6-(methylamino)pyrimidin-4(3H)-one

Downstream raw materials:

trans-[Pt(NH₃)(cyclohexylamine)(9-methylhypoxanthine-N₇)Cl]⁽¹⁺⁾

trans-[Pt(NH₃)(cyclohexylamine)(9-methylhypoxanthine-N₇)(H₂O)]⁽²⁺⁾

trans-[Pt(NH₃)(cyclohexylamine)(9-methylhypoxanthine-N₇)2]⁽²⁺⁾

[Pd(2-(dimethylaminomethyl)phenyl-C,N)(9-methylhypoxanthine)(PPh₃)](perchlorate)

Refernces

• 1、 Wahab Khan,Uddin, Mohammed Kabir,Ali, Morshed,Rahman, Mohammad S.,Rashid, Mohammad Abdur,Chowdhury, Rasheduzzaman. "A convenient synthesis of new annelated pyrimidines and their biological importance". . p. E216-E221. Retrieved 2014/11/07.
• 2、 Itaya, Taisuke,Ogawa, Kazuo,Takada, Yasutaka,Fujii, Tozo. "Purines. LXXII. Oxidation of N6-alkyladenines with m-chloroperoxybenzoic acid leading to N6-alkyladenine 1-oxides". . p. 967 - 971. Retrieved 2007/10/03.