3-Pyridinesulfonic acid, 6-methoxy-, 3,4,5-trimethoxyphenyl ester

Base Information

• Chemical Name: 3-Pyridinesulfonic acid, 6-methoxy-, 3,4,5-trimethoxyphenyl ester
• CAS No.: 312299-87-9
• Molecular Formula: C15H17NO7S
• Molecular Weight: 355.368
• Mol file: 312299-87-9.mol

Synonyms:

Chemical Property of 3-Pyridinesulfonic acid, 6-methoxy-, 3,4,5-trimethoxyphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Pyridinesulfonic acid, 6-methoxy-, 3,4,5-trimethoxyphenyl ester

There total 2 articles about 3-Pyridinesulfonic acid, 6-methoxy-, 3,4,5-trimethoxyphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3,4,5-trimethoxyphenol (642-71-7) + 6-methoxypyridin-3-ylsulfonyl chloride (312300-42-8) → 3,4,5-trimethoxyphenyl 6-methoxy-3-pyridinesulfonate (312299-87-9)

Guidance literature:

With pyridine; dmap; In dichloromethane;

DOI:10.1016/S0960-894X(01)00098-1

Reference yield:

6-methoxy-pyridin-3-ylamine (6628-77-9) → 3,4,5-trimethoxyphenyl 6-methoxy-3-pyridinesulfonate (312299-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaNO₂

1.2: 41 percent / SO₂; CuCl₂

2.1: 83 percent / pyridine; DMAP / CH₂Cl₂

With pyridine; dmap; sodium nitrite; In dichloromethane;

DOI:10.1016/S0960-894X(01)00098-1

Reference yield: 45.0%

3,4,5-trimethoxyphenyl 6-methoxy-3-pyridinesulfonate (312299-87-9) + methyl iodide (74-88-4) → 1-methyl-6-oxo-1,6-dihydro-pyridine-3-sulfonic acid 3,4,5-trimethoxy-phenyl ester

Guidance literature:

at 135 ℃;

DOI:10.1016/S0960-894X(01)00098-1

upstream raw materials:

3,4,5-trimethoxyphenol

6-methoxypyridin-3-ylsulfonyl chloride

6-methoxy-pyridin-3-ylamine

Refernces

• 1、 Gwaltney II, Stephen L.,Imade, Hovis M.,Barr, Kenneth J.,Li, Qun,Gehrke, Laura,Credo,Warner, Robert B.,Lee, Jang Yun,Kovar, Peter,Wang, Jieyi,Nukkala, Michael A.,Zielinski, Nicolette A.,Frost, David,Ng, Shi-Chung,Sham, Hing L.. "Novel sulfonate analogues of combretastatin A-4: Potent antimitotic agents". . p. 871 - 874. Retrieved 2007/10/03.