Ethane, 1,2-bis(2-bromoethoxy)-

Base Information

• Chemical Name: Ethane, 1,2-bis(2-bromoethoxy)-
• CAS No.: 31255-10-4
• Molecular Formula: C6H12Br2O2
• Molecular Weight: 275.968
• Mol file: 31255-10-4.mol

Synonyms:1-Bromo-2-[2-(2-bromoethoxy)ethoxy]ethane;

Chemical Property of Ethane, 1,2-bis(2-bromoethoxy)-

Chemical Property:

• Boiling Point: 285.1 °C at 760 mmHg
• Flash Point: 113.8 °C
• PSA: 18.46000
• Density: 1.655 g/cm³
• LogP: 1.80940
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform, Ethyl Acetate (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

1,2-bis(2-bromoethoxy)ethane 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Bromo-PEG2-bromide is a PEG linker containing two bromide groups. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.

Technology Process of Ethane, 1,2-bis(2-bromoethoxy)-

There total 9 articles about Ethane, 1,2-bis(2-bromoethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,2'-[1,2-ethanediylbis(oxy)]bisethanol (112-27-6) → 1,2-bis-(2-bromo-ethoxy)-ethane (31255-10-4)

Guidance literature:

2,2'-[1,2-ethanediylbis(oxy)]bisethanol; With carbon tetrabromide; In dichloromethane; for 0.25h;

With triphenylphosphine; In dichloromethane; at 20 ℃;

DOI:10.1039/b719702k

Reference yield: 76.0%

triethylene glycol di-(p-toluenesulfonate) (19249-03-7) → 1,2-bis-(2-bromo-ethoxy)-ethane (31255-10-4)

Guidance literature:

With ammonium bromide; In N,N-dimethyl-formamide; at 85 ℃; for 5h; Further Variations:; Solvents; Product distribution;

DOI:10.1016/j.tetlet.2007.05.081

Reference yield: 69.0%

→ 1,2-bis-(2-bromo-ethoxy)-ethane (31255-10-4)

Guidance literature:

upstream raw materials:

oxirane

ethene

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

1,4-dioxane

Downstream raw materials:

1,4-bis{2-[2-(2-bromoethoxy)ethoxy]ethoxy}benzene

7,10,13-tris(p-tolylsulphonyl)-1,4-dioxa-7,10,13-triazacyclopentadecane

1,10-bis-1,4,7,10-tetraoxadecane

N,N'-dibenzyl-1,8-diamino-3,6-dioxaoctane dihydrochloride

Refernces

• 1、 Kumar, Krishan,Barrn-Berdn, Ana L.,Datta, Sougata,Muoz-beda, Mnica,Aicart-Ramos, Clara,Kondaiah, Paturu,Junquera, Elena,Bhattacharya, Santanu,Aicart, Emilio. "A delocalizable cationic headgroup together with an oligo-oxyethylene spacer in gemini cationic lipids improves their biological activity as vectors of plasmid DNA". . p. 1495 - 1506. Retrieved 2015.
• 2、 Li, Guo,Huang, Tianci,Xie, Mingjuan,Zhang, Xiangxiang,Yu, Qi,Liu, Shujuan,Yang, Tianshe,Zhao, Qiang. "A platinum(II)-acetylide-based conjugated polyelectrolyte for hypoxia imaging via ratiometric and time-resolved luminescence microscopy". . p. 144 - 149. Retrieved 2019.
• 3、 Li, Yi,Dong, Jianming,Xun, Zhiqing,Zeng, Yi,Yu, Tianjun,Han, Yongbin,Chen, Jinping,Li, Ying-Ying,Yang, Guoqiang. "A versatile and robust vesicle based on a photocleavable surfactant for two-photon-tuned release". . p. 7931 - 7936. Retrieved 2013.
• 4、 Dreja, Michael,Gramberg, Susanne,Tieke, Bernd. "Cationic amphitropic gemini surfactants with hydrophilic oligo(oxyethylene) spacer chains". . p. 1371 - 1372. Retrieved 1998.
• 5、 -. "Photochromic controlled permeable small molecule cross-linked vesicle as well as preparation method and application thereof". Paragraph 0045-0047. . Retrieved 2021/09/01.
• 6、 -. "MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE". Paragraph 001432-001433. . Retrieved 2019/10/29.