2-(1-METHYL-5-NITRO-1H-IMIDAZOL-2-YL)-PROPAN-2-OL

Base Information

• Chemical Name: 2-(1-METHYL-5-NITRO-1H-IMIDAZOL-2-YL)-PROPAN-2-OL
• CAS No.: 35175-14-5
• Molecular Formula: C₇H₁₁N₃O₃
• Molecular Weight: 185.183
• Hs Code.: 2933290090
• Mol file: 35175-14-5.mol

Synonyms:1,a,a-Trimethyl-5-nitroimidiazole-2-methanol;2-(1-Hydroxy-1-methylethyl)-1-methyl-5-nitroimidazole;Hydroxyipronidazole;L12407;

Chemical Property of 2-(1-METHYL-5-NITRO-1H-IMIDAZOL-2-YL)-PROPAN-2-OL

Chemical Property:

• Vapor Pressure: 4.69E-06mmHg at 25°C
• Melting Point: 108-110°C
• Refractive Index: 1.579
• Boiling Point: 367.7 °C at 760 mmHg
• PKA: 13.44±0.29(Predicted)
• Flash Point: 176.2 °C
• PSA: 83.87000
• Density: 1.34 g/cm³
• LogP: 1.07890
• Storage Temp.: -20?C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

Hydroxy ipronidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: The alcohol metabolite of Ipronidazole (I747000).

Technology Process of 2-(1-METHYL-5-NITRO-1H-IMIDAZOL-2-YL)-PROPAN-2-OL

There total 3 articles about 2-(1-METHYL-5-NITRO-1H-IMIDAZOL-2-YL)-PROPAN-2-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.8%

2-N hydrochloric acid + sodium tert.amylate + ipronidazole (14885-29-1) → 1-methyl-2-(2'-hydroxyisopropyl)-5-nitroimidazole (35175-14-5)

Guidance literature:

With triethyl phosphite; In N-methyl-acetamide; water; ethyl acetate; toluene;

Reference yield: 21.6%

di-isopropyl ether (108-20-3) + ipronidazole (14885-29-1) → 1-methyl-2-(2'-hydroxyisopropyl)-5-nitroimidazole (35175-14-5)

Guidance literature:

With potassium hydroxide; triethyl phosphite; In N,N,N,N,N,N-hexamethylphosphoric triamide; water; acetic acid;

Reference yield:

→ 1-methyl-2-(2'-hydroxyisopropyl)-5-nitroimidazole (35175-14-5)

Guidance literature:

/BRN= 881010/, Me2SO4;

upstream raw materials:

di-isopropyl ether

ipronidazole

Refernces