Technology Process of 4-Nonenamide,
7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-N,N,8-trimethyl-2-(1-
methylethyl)-, (2S,4E,7R)-
There total 67 articles about 4-Nonenamide,
7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-N,N,8-trimethyl-2-(1-
methylethyl)-, (2S,4E,7R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane;
With
magnesium; ethylene dibromide;
In
2-methyltetrahydrofuran;
at 60 - 65 ℃;
trans-(2S)-5-chloro-2-isopropyl-N,N-dimethyl-4-pentenamide;
iron(III)-acetylacetonate;
In
2-methyltetrahydrofuran; 1-methyl-pyrrolidin-2-one;
at 10 ℃;
for 0.25h;
Product distribution / selectivity;
- Guidance literature:
-
With
triethylsilane; trifluoroacetic acid;
In
ethyl acetate; 1,2-dichloro-ethane;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium carbonate; potassium iodide / acetonitrile / 24 h / Reflux
2.1: n-butyllithium / tetrahydrofuran; hexane / 3 h / -78 °C
2.2: 1 h / -78 - 20 °C
3.1: aluminum (III) chloride; lithium aluminium tetrahydride / diethyl ether / 1 h / 20 °C
4.1: osmium(VIII) oxide; sodium periodate; 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran; water; tert-butyl alcohol / 4 h / 0 °C
5.1: lithium borohydride / tetrahydrofuran / 1 h / 20 °C
6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.5 h / -40 - 20 °C
7.1: dihydrogen peroxide; ammonium molybdate / ethanol / 24 h / 20 °C
8.1: sodium hexamethyldisilazane / 1,2-dimethoxyethane / 1 h / -70 °C
8.2: 1 h / -70 °C
With
1,4-diaza-bicyclo[2.2.2]octane; aluminum (III) chloride; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; lithium borohydride; n-butyllithium; ammonium molybdate; dihydrogen peroxide; sodium hexamethyldisilazane; potassium carbonate; triphenylphosphine; potassium iodide; diethylazodicarboxylate;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol; hexane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1039/c4ob01963f
