5-Bromo-2-methoxyphenol

Base Information

• Chemical Name: 5-Bromo-2-methoxyphenol
• CAS No.: 37942-01-1
• Molecular Formula: C7H7BrO2
• Molecular Weight: 203.035
• Hs Code.: 29095000
• DSSTox Substance ID: DTXSID20191383
• Nikkaji Number: J801.796D
• Wikidata: Q72446312
• Mol file: 37942-01-1.mol

Synonyms:5-Bromo-2-methoxyphenol;37942-01-1;4-Bromo-2-hydroxyanisole;Phenol, 5-bromo-2-methoxy-;5-Bromo-2-methoxy-phenol;3-Hydroxy-4-methoxybromobenzene;2-methoxy-5-bromophenol;MFCD00673137;p-Bromguajacol;Phenol, 5-bromo-2-methoxy-,;3-HYDROXY-4-METHOXY BROMOBENZENE;5-bromo-2-methoxylphenol;SCHEMBL41497;3-hydroxy-4-methoxy-bromobenzene;DTXSID20191383;BCP13373;1-Methoxy-2-hydroxy-4-bromo-benzene;AKOS015834760;AC-8353;CS-W007658;FS-2337;SB67356;SY051105;A6447;AM20040326;B3342;FT-0658860;EN300-206667;J-516959;1-Chloro-4-[2-chloro-1-(4-chlorophenyl)vinyl]benzene

Chemical Property of 5-Bromo-2-methoxyphenol

Chemical Property:

• Appearance/Colour: crystalline powder
• Vapor Pressure: 0.00789mmHg at 25°C
• Melting Point: 64-70 °C
• Refractive Index: 1.578
• Boiling Point: 259.7 °C at 760 mmHg
• PKA: 9.01±0.10(Predicted)
• Flash Point: 110.9 °C
• PSA: 29.46000
• Density: 1.585 g/cm³
• LogP: 2.16330
• Storage Temp.: Store Cold
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 201.96294
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-2-methoxyphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)Br)O

Technology Process of 5-Bromo-2-methoxyphenol

There total 28 articles about 5-Bromo-2-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methoxyphenyl mesylate (98910-57-7) → 5-bromo-2-methoxyphenol (37942-01-1)

Guidance literature:

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; In acetic acid; at 15 ℃; for 3h; Inert atmosphere;

Reference yield: 92.0%

5-bromo-2-methoxybenzaldehyde (25016-01-7) → 5-bromo-2-methoxyphenol (37942-01-1)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1016/S0968-0896(02)00604-1

Reference yield: 91.0%

2,4-dibromoanisole (21702-84-1) → 5-bromo-2-methoxyphenol (37942-01-1)

Guidance literature:

2,4-dibromoanisole; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 1h;

With Trimethyl borate; In diethyl ether; hexane; at -78 - 20 ℃;

With dihydrogen peroxide; acetic acid; In diethyl ether; hexane; water; at 20 ℃; for 16h;

DOI:10.1016/j.tet.2005.10.014

upstream raw materials:

2,4-dibromoanisole

1-acetoxy-5-bromo-2-methoxybenzene

carbonic acid bis-(5-bromo-2-methoxy-phenyl ester)

5-amino-2-methoxyphenol

Downstream raw materials:

4-bromo-2-hydroxy-1-methoxy-thioxanthen-9-one

1-Bromo-3-ethoxy-4-methoxybenzene

4-bromo-2,2-(2-indanyloxy)anisole

4-bromo-2-cyclopentyloxyanisole

Refernces

• 1、 -. "Methods for preparation of apremilast". . . Retrieved 2021/05/19.
• 2、 Liu, Jie,Ma, Xuebing,Wang, Xuri,Xie, Guangxin,Yin, Zuyong,Zhang, Jianing. "Hollow, mesoporous, eutectic Zn1?xMgxO nano-spheres as solid acid-base catalysts for the highly regio-selectiveO-methylation of 1,2-diphenols". . p. 7454 - 7466. Retrieved 2021/11/23.