3H-Pyrrolizin-3-one, hexahydro-

Base Information

• Chemical Name: 3H-Pyrrolizin-3-one, hexahydro-
• CAS No.: 32548-24-6
• Molecular Formula: C7H11NO
• Molecular Weight: 125.17
• Mol file: 32548-24-6.mol

Synonyms:Hexahydropyrrolizin-3-one;pyrrolizidin-3-one;1,2,5,6,7,8-hexahydro-3H-pyrrolizin-3-one;3H-Pyrrolizin-3-one,hexahydro;Hexahydro-3H-pyrrolizin-3-one;Hexahydro-pyrrolizin-3-on;3-pyrrolizidone;

Chemical Property of 3H-Pyrrolizin-3-one, hexahydro-

Chemical Property:

• PSA: 20.31000
• LogP: 0.70910

Purity/Quality:

99% ^*data from raw suppliers

Hexahydro-pyrrolizin-3-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3H-Pyrrolizin-3-one, hexahydro-

There total 21 articles about 3H-Pyrrolizin-3-one, hexahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

Pyrrolizin-3-one (34610-37-2) → 1,2,5,6,7,8-hexahydro-3H-pyrrolizin-3-one (32548-24-6)

Guidance literature:

With 5% Pd(II)/C(eggshell); hydrogen; In ethanol; at 20 ℃; for 2h; under 2327.23 Torr;

DOI:10.1039/b910199c

Reference yield: 89.0%

methyl 1-[(1,1-dimethylethoxy)carbonyl]-2-pyrrolidinepropanoate (190734-68-0) → 1,2,5,6,7,8-hexahydro-3H-pyrrolizin-3-one (32548-24-6)

Guidance literature:

With chloro-trimethyl-silane; phenol; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jo016053w

Reference yield: 85.0%

7-amino-heptanoic acid lactam (673-66-5) → 1,2,5,6,7,8-hexahydro-3H-pyrrolizin-3-one (32548-24-6)

Guidance literature:

With calcium hydroxide; lithium bromide; In 1,4-dioxane; water; at 85 ℃; for 3.5h; electrolyses;

upstream raw materials:

7-amino-heptanoic acid lactam

1,2-dihydropyrrolizin-3-one

pyrrolidine

acrylic acid methyl ester

Downstream raw materials:

pyrrolizidine

Refernces

• 1、 Santiago, Jo?o Victor,Burtoloso, Antonio C. B.. "Rapid Synthesis of Bicyclic N-Heterocyclic Cores from N-Terminal α,β-Unsaturated Diazoketones". . p. 2822 - 2830. Retrieved 2018/06/04.
• 2、 Shankaran,Donnelly, Karla L.,Shah, Shrenik K.,Guthikonda, Ravindra N.,MacCoss, Malcolm,Humes, John L.,Pacholok, Stephen G.,Grant, Stephan K.,Kelly,Wong. "Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase". . p. 4539 - 4544. Retrieved 2007/10/03.