8-ketodeoxycoformycin

Base Information

• Chemical Name: 8-ketodeoxycoformycin
• CAS No.: 69196-03-8
• Molecular Formula: C11H14 N4 O4
• Molecular Weight: 266.257
• Mol file: 69196-03-8.mol

Synonyms:8-ketodeoxycoformycin

Chemical Property of 8-ketodeoxycoformycin

Chemical Property:

• Vapor Pressure: 3.05E-18mmHg at 25°C
• Boiling Point: 658.6°C at 760 mmHg
• Flash Point: 352.1°C
• Density: 1.8g/cm³

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-ketodeoxycoformycin

There total 7 articles about 8-ketodeoxycoformycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-((2R,4S,5R)-4-p-Tolyloxy-5-p-tolyloxymethyl-tetrahydro-furan-2-yl)-6,7-dihydro-3H-imidazo[4,5-d][1,3]diazepin-8-one; compound with methanol → 3-(2-deoxy-β-D-erythro-pentofuranosyl)-6,7-dihydroimidazo<4,5-d><1,3>diazepin-8(3H)-one (69196-03-8)

Guidance literature:

With methanol; sodium; for 1h;

DOI:10.1021/jo00139a015

Reference yield: 78.0%

2'-deoxyuridine (951-78-0,63844-76-8) + 6,7-dihydroimidazo-[4,5-d][1,3]diazepine-8(3H)-one hydrochloride monodimethylsulfoxide → 3-(2-deoxy-β-D-erythro-pentofuranosyl)-6,7-dihydroimidazo<4,5-d><1,3>diazepin-8(3H)-one (69196-03-8)

Guidance literature:

With potassium chloride; In aq. phosphate buffer; at 25 - 30 ℃; for 3h; pH=8; Enzymatic reaction;

Reference yield:

5-chloro-2-(((4-chlorobenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-chlorobenzoate (3601-90-9) → 3-(2-deoxy-β-D-erythro-pentofuranosyl)-6,7-dihydroimidazo<4,5-d><1,3>diazepin-8(3H)-one (69196-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine; 2,2,2-trifluoro-N,N-bis(trimethylsilyl)-acetamide / acetonitrile / 12 h

1.2: 0.17 h / -50 - -35 °C

1.3: 1 h

2.1: ammonia / methanol / 24 h / 20 °C

With pyridine; 2,2,2-trifluoro-N,N-bis(trimethylsilyl)-acetamide; ammonia; In methanol; acetonitrile;

upstream raw materials:

2-deoxyinosine

diazomethane diethyl ether

2'-deoxyuridine

6,7-dihydroimidazo<4,5-d><1,3>diazepin-8(3H)-one

Downstream raw materials:

(S)-pentostatin

2'-deoxycoformycin

Refernces

• 1、 -. "SYNTHESIS AND MANUFACTURE OF PENTOSTATIN AND ITS PRECURSORS, ANALOGS AND DERIVATIVES". Page/Page column 7. . Retrieved 2008/06/13.