6-Chloro-9-(trimethylsilyl)-9H-purine

Base Information

• Chemical Name: 6-Chloro-9-(trimethylsilyl)-9H-purine
• CAS No.: 32865-86-4
• Molecular Formula: C8H11ClN4Si
• Molecular Weight: 226.741
• Mol file: 32865-86-4.mol

Synonyms:6-chloro-9-trimethylsilylpurine;6-chloro-9-trimethylsilanyl-9H-purine;

Chemical Property of 6-Chloro-9-(trimethylsilyl)-9H-purine

Chemical Property:

• PSA: 43.60000
• LogP: 2.16270

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Chloro-9-(trimethylsilyl)-9H-purine

There total 11 articles about 6-Chloro-9-(trimethylsilyl)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-chloropurine (87-42-3) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → 6-chloro-9-trimethylsilylpurine (32865-86-4)

Guidance literature:

With chloro-trimethyl-silane; for 2h; Heating;

DOI:10.1021/jm00168a006

Reference yield:

N,O-bis-(trimethylsilyl)-acetamide (10416-59-8) + 6-chloropurine (87-42-3) → 6-chloro-9-trimethylsilylpurine (32865-86-4)

Guidance literature:

In acetonitrile; for 18h; Heating;

DOI:10.1135/cccc20061063

Reference yield:

chloro-trimethyl-silane (75-77-4) + 6-chloropurine (87-42-3) → 6-chloro-9-trimethylsilylpurine (32865-86-4)

Guidance literature:

With triethylamine; In benzene; for 48h;

DOI:10.1021/jm00361a023

upstream raw materials:

chloro-trimethyl-silane

6-chloropurine

1,1,1,2,2,2-hexamethyldisilane

1,1,1,3,3,3-hexamethyl-disilazane

Downstream raw materials:

2',3',5'-O-triacetyl-6-chloroinosine

(-)-9-[(1S,2S,4R)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselenyl-4-thio-β-L-ribofuranosyl]-6-chloropurine

9-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselanyl-4-thio-β-D-pentofuranosyl]-6-chloropurine

2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-3-(6-chloro-purin-9-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

Refernces

• 1、 Liu, Lian Jin,Kim, Eunae,Hong, Joon Hee. "Design and synthesis of novel threosyl-5′-deoxyphosphonic acid purine analogues as potent anti-HIV agents". . p. 411 - 422. Retrieved 2012.
• 2、 van Tilburg,van der Klein,von Frijtag Drabbe Kuenzel,de Groote,Stannek,Lorenzen,IJzerman. "5'-O-alkyl ethers of N,2-substituted adenosine derivatives: partial agonists for the adenosine A1 and A3 receptors.". . p. 2966 - 2975. Retrieved 2001.
• 3、 Jouffroy, Lucile,Verhoeven, Jonas,Brambilla, Marta,Verniest, Guido,Kong, Hanchu,Zhao, Yongbin,Wang, Wenbin,Meerpoel, Lieven,Thuring, Jan Willem,Winne, Johan M.. "Regio- And Stereoselective Synthesis of C-4′ Spirocyclobutyl Ribofuranose Scaffolds and Their Use as Biologically Active Nucleoside Analogues". supporting information. p. 8828 - 8833. Retrieved 2021/11/20.
• 4、 Lee, Hyejin,Jarhad, Dnyandev B.,Yu, Jinha,Lee, Choongho,Jeong, Lak Shin. "Asymmetric Synthesis of 2′- C-Methyl-4′-selenonucleosides as Anti-Hepatitis C Virus Agents". . p. 14414 - 14426. Retrieved 2019/11/11.