2-acetyl-4-methoxyphenyl 4-nitrobenzoate

Base Information

• Chemical Name: 2-acetyl-4-methoxyphenyl 4-nitrobenzoate
• CAS No.: 332103-23-8
• Molecular Formula: C16H13NO6
• Molecular Weight: 315.282
• Mol file: 332103-23-8.mol

Synonyms:1-[5-methoxy-2-(4-nitro-benzoyloxy)-phenyl]-ethanone;4-Nitro-benzoic acid 2-acetyl-4-methoxy-phenyl ester;2-acetyl-4-methoxyphenyl 4-nitrobenzoate;1-[5-Methoxy-2-(4-nitro-benzoyloxy)-phenyl]-aethanon;

Chemical Property of 2-acetyl-4-methoxyphenyl 4-nitrobenzoate

Chemical Property:

• Melting Point: 146 - 147 °C (ethanol)
• Boiling Point: 532.3±50.0 °C(Predicted)
• PSA: 98.42000
• Density: 1.312±0.06 g/cm3(Predicted)
• LogP: 3.54840

Purity/Quality:

(2-ACETYL-4-METHOXYPHENYL) 4-NITROBENZOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-acetyl-4-methoxyphenyl 4-nitrobenzoate

There total 2 articles about 2-acetyl-4-methoxyphenyl 4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.4%

1-(2-hydroxy-5-methoxyphenyl)ethan-1-one (705-15-7) + 4-nitro-benzoyl chloride (122-04-3) → 4-nitrobenzoic acid 2-acetyl-4-methoxyphenyl ester (332103-23-8)

Guidance literature:

With pyridine; at 20 ℃; for 3h;

DOI:10.1016/j.bmc.2009.01.025

Reference yield:

pyridine (110-86-1) + 1-(2-hydroxy-5-methoxyphenyl)ethan-1-one (705-15-7) + 4-nitro-benzoyl chloride (122-04-3) → 4-nitrobenzoic acid 2-acetyl-4-methoxyphenyl ester (332103-23-8)

Guidance literature:

Reference yield: 97.4%

4-nitrobenzoic acid 2-acetyl-4-methoxyphenyl ester (332103-23-8) → 1-(5-methoxy-2-hydroxyphenyl)-3-(4-nitrophenyl)propane-1,3-dione (857232-60-1)

Guidance literature:

4-nitrobenzoic acid 2-acetyl-4-methoxyphenyl ester; With potassium hydroxide; In pyridine; at 50 ℃; for 0.25h;

With acetic acid; In pyridine; water; at 0 ℃;

upstream raw materials:

pyridine

1-(2-hydroxy-5-methoxyphenyl)ethan-1-one

4-nitro-benzoyl chloride

Downstream raw materials:

6-methoxy-2-(4-nitrophenyl)-4H-chromen-4-one

1-(5-methoxy-2-hydroxyphenyl)-3-(4-nitrophenyl)propane-1,3-dione

Refernces

• 1、 Ono, Masahiro,Watanabe, Rumi,Kawashima, Hidekazu,Kawai, Tomoki,Watanabe, Hiroyuki,Haratake, Mamoru,Saji, Hideo,Nakayama, Morio. "18F-labeled flavones for in vivo imaging of β-amyloid plaques in Alzheimer's brains". experimental part. p. 2069 - 2076. Retrieved 2009/06/06.