122-04-3 Usage
Description
4-Nitrobenzoyl chloride is a chemical compound that exists in the form of yellow needles or powder and has a pungent odor. It is known for its chemical properties, which include being a yellow-colored solid in the form of needles or powder.
Uses
Used in Organic Synthesis:
4-Nitrobenzoyl chloride is used as a reagent in various organic synthesis processes, such as Michael additions, Henry reactions, O-alkylation, and cycloaddition reactions. These reactions are crucial for the creation of different organic compounds and contribute to the compound's versatility in chemical applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Nitrobenzoyl chloride is utilized as an intermediate in the production of active pharmaceutical ingredients. Its role in the synthesis of various drugs highlights its importance in the development of new medications and therapies.
Used in Dye Industry:
4-Nitrobenzoyl chloride is also employed in the dye industry, where it serves as an intermediate for the synthesis of different types of dyes. This application showcases the compound's ability to contribute to the creation of a wide range of products across various industries.
Used in Synthesis of Polysubstituted Furanonaphthoquinoines:
4-Nitrobenzoyl chloride is specifically used in the synthesis of polysubstituted furanonaphthoquinoines, which are complex organic compounds with potential applications in various fields, including pharmaceuticals and materials science.
Air & Water Reactions
Unstable in moist surroundings and should be kept in a tightly-closed container. React with water or steam .
Reactivity Profile
4-Nitrobenzoyl chloride is incompatible with bases (including amines), with strong oxidizing agents, and with alcohols. May react with reducing agents. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health Hazard
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Flash point data are not available for 4-Nitrobenzoyl chloride, but 4-Nitrobenzoyl chloride is combustible.
Safety Profile
Moderately toxic by
ingestion. Experimental reproductive
effects. Mutation data reported. When
heated to decomposition it emits toxic
fumes of NOx and Cl-. See also NITRO
COhlPOUNDS OF AROMATIC
HYDROCARBONS and CHLORIDES.
Purification Methods
Crystallise the acid chloride from dry pet ether (b 60-80o), *C6H6 or CCl4. Distil it under vacuum. Irritant. [Adama & Jenkins Org Synth Coll Vol I 394 1941, Beilstein 9 III 1709, 9 IV 1191.]
Check Digit Verification of cas no
The CAS Registry Mumber 122-04-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 2 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 122-04:
(5*1)+(4*2)+(3*2)+(2*0)+(1*4)=23
23 % 10 = 3
So 122-04-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H4ClNO3/c8-7(10)5-1-3-6(4-2-5)9(11)12/h1-4H
122-04-3Relevant articles and documents
Synthesis and antibacterial activity of some N-(3-hydroxy-2-pyridyl) benzamides
Mobinikhaledi,Forughifar,Shariatzadeh,Fallah
, p. 427 - 430 (2006)
N-(3-Hydroxy-2-pyridyl)benzamides 3(a-J) were synthesized under weak basic solution by reacting of 2-amino-3-pyridinol and an appropriate carboxylic acid chloride, obtained by reaction of carboxylic acids with thionyl chloride. The microbiological activity of these compounds was tested in vitro against Escherichia Coil (PTCC 1338), Pseudomonas aeruginosa (PTCC 1074), Entrococcus faecalis (PTCC 1237) and Staphylococcus aureus (PTCC 1119) bacteria. Compounds 3a, 3e and 3f were the active benzamide derivatives against the Ef and Sa bacteria with a MIC value of 128 μg/ml. Compound 3g was the active entry against Ec and Pa bacteria with a MIC value of 128 μg/.
Chemically assisted directed assembly of carbon nanotubes for the fabrication of large-scale device arrays
Tulevski, George S.,Hannon, James,Afzali, Ali,Chen, Zhihong,Avouris, Phaedon,Kagan, Cherie R.
, p. 11964 - 11968 (2007)
We report the directed assembly of single-walled carbon nanotubes (SWCNTs) at lithographically defined positions on gate oxide surfaces, allowing for the high yield (~90%) and parallel fabrication of SWCNT device arrays. SWCNTs were first chemically funct
Stereoselective Synthesis of a cis-Cedrane-8,9-diol as a Key Intermediate for an Amber Odorant
Stefanow, Vivian,Grandane, Aiga,Eh, Marcus,Panten, Johannes,Spannenberg, Anke,Werner, Thomas
supporting information, p. 89 - 97 (2021/01/09)
The naturally occurring (-)-α-cedrene exhibits a weak woody and cedarlike odor. In contrast, cis-cedrene acetonide, which is a derivative of cedrene, is an extremely powerful semisynthetic aroma molecule. The current process starting from cedrene yields cis-cedrene acetonide in an overall yield of 99% yield.
1, 8-naphthalic anhydride derivatives containing 8-(benzoylamino) quinoline as well as synthesis and application thereof
-
Paragraph 0016; 0024-0026, (2021/02/20)
The invention discloses naphthalene anhydride derivatives containing 8-(benzoylamino) quinoline as well as a preparation method and application thereof, and belongs to the field of biological organicsynthesis. According to the naphthalic anhydride derivat