101575-64-8Relevant articles and documents
A short scalable route to (-)-α-kainic acid using Pt-catalyzed direct allylic amination
Zhang, Ming,Watanabe, Kenji,Tsukamoto, Masafumi,Shibuya, Ryozo,Morimoto, Hiroyuki,Ohshima, Takashi
, p. 3937 - 3941 (2014)
An increased supply of scarce or inaccessible natural products is essential for the development of more sophisticated pharmaceutical agents and biological tools, and thus the development of atom-economical, step-economical and scalable processes to access these natural products is in high demand. Herein we report the development of a short, scalable total synthesis of (-)-α-kainic acid, a useful compound in neuropharmacology that is, however, limited in supply from natural resources. The synthesis features sequential platinum-catalyzed direct allylic aminations and thermal ene-cyclization, enabling the gram-scale synthesis of (-)-α-kainic acid in six steps and 34% overall yield.