1-BroMo-2-fluoronaphthalene

Base Information

• Chemical Name: 1-BroMo-2-fluoronaphthalene
• CAS No.: 342-55-2
• Molecular Formula: C10H6BrF
• Molecular Weight: 225.06
• Hs Code.: 2903999090
• Mol file: 342-55-2.mol

Synonyms:2-Fluor-1-bromnaphthalin;1-Brom-2-fluor-naphthalin;1-bromo-2-fluoro-naphthalene;1-Brom-2-fluornaphtalin;Naphthalene,1-bromo-2-fluoro;

Chemical Property of 1-BroMo-2-fluoronaphthalene

Chemical Property:

• PSA: 0.00000
• LogP: 3.74140

Purity/Quality:

98%min ^*data from raw suppliers

1-Bromo-2-fluoronaphthalene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Bromo-2-fluoronaphthalene is used in the synthesis of novel benz[a]anthracenes as well as napthalenes, each with their own respective pharmaceutical properties.

Technology Process of 1-BroMo-2-fluoronaphthalene

There total 6 articles about 1-BroMo-2-fluoronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-2-naphthylamine hydrochloride (80413-60-1) → 1-bromo-2-fluoro-naphthalene (342-55-2)

Guidance literature:

1-bromo-2-naphthylamine hydrochloride; With hydrogenchloride; sodium nitrite; In water; for 0.5h;

With tetrafluoroboric acid; In water; for 0.5h;

DOI:10.1080/00304948.2020.1714320

Reference yield:

N-(1-bromonaphthalen-2-yl)acetamide (7597-73-1) → 1-bromo-2-fluoro-naphthalene (342-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / ethanol; water / 1.5 h / Reflux

2.1: hydrogenchloride; sodium nitrite / water / 0.5 h

2.2: 0.5 h

With hydrogenchloride; sodium nitrite; In ethanol; water;

DOI:10.1080/00304948.2020.1714320

Reference yield:

naphthalen-2-ylamine (91-59-8) → 1-bromo-2-fluoro-naphthalene (342-55-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic acid / 0.42 h / Reflux

1.2: 2 h / 25 °C

2.1: hydrogenchloride / ethanol; water / 1.5 h / Reflux

3.1: hydrogenchloride; sodium nitrite / water / 0.5 h

3.2: 0.5 h

With hydrogenchloride; acetic acid; sodium nitrite; In ethanol; water;

DOI:10.1080/00304948.2020.1714320

upstream raw materials:

1-bromo-2-naphthylamine

N-(1-bromonaphthalen-2-yl)acetamide

1-bromo-2-naphthylamine hydrochloride

naphthalen-2-ylamine

Downstream raw materials:

1-Acetyl-2-fluornaphthalin

(2-fluoro-naphth-1-yl)di(phenyl)phosphine

3-Fluor-1-cyanonaphthalin

Refernces

• 1、 Repine, Joseph T.,Johnson, Douglas S.,White, Andrew D.,Favor, David A.,Stier, Michael A.,Yip, Judy,Rankin, Trent,Ding, Qizhu,Maiti, Samarendra N.. "Synthesis of monofluorinated 1-(naphthalen-1-yl)piperazines". . p. 5539 - 5541. Retrieved 2008/02/13.